Homotypic versican G1 domain interactions enhance hyaluronan incorporation into fibrillin microfibrils

Yusuke Murasawa; Ken Watanabe; Masahiko Yoneda; Masahiro Zako; Koji Kimata; Lynn Y. Sakai; Zenzo Isogai

doi:10.1074/jbc.M113.456947

Homotypic versican G1 domain interactions enhance hyaluronan incorporation into fibrillin microfibrils

Yusuke Murasawa, Ken Watanabe, Masahiko Yoneda, Masahiro Zako, Koji Kimata, Lynn Y. Sakai, Zenzo Isogai

Molecular and Medical Genetics

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background:Versican interacts with hyaluronan (HA) via its G1 domain and with fibrillin microfibrils via its G3 domain. However, the roles of versican G1 domain-containing fragments (VG1Fs) in the HA-versican-microfibril macrocomplex are not clear. Results:VG1Fs interact homotypically and are recaptured by versican-containing fibrillin microfibrils. Conclusion:Homotypical interactions of VG1Fs enhance HA recruitment to microfibrils. Significance:VG1Fs stabilize HA-versican-microfibril macrocomplexes.

Original language	English (US)
Pages (from-to)	29170-29181
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.456947
State	Published - Oct 4 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Homotypic versican G1 domain interactions enhance hyaluronan incorporation into fibrillin microfibrils",

abstract = "Background:Versican interacts with hyaluronan (HA) via its G1 domain and with fibrillin microfibrils via its G3 domain. However, the roles of versican G1 domain-containing fragments (VG1Fs) in the HA-versican-microfibril macrocomplex are not clear. Results:VG1Fs interact homotypically and are recaptured by versican-containing fibrillin microfibrils. Conclusion:Homotypical interactions of VG1Fs enhance HA recruitment to microfibrils. Significance:VG1Fs stabilize HA-versican-microfibril macrocomplexes.",

author = "Yusuke Murasawa and Ken Watanabe and Masahiko Yoneda and Masahiro Zako and Koji Kimata and Sakai, {Lynn Y.} and Zenzo Isogai",

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doi = "10.1074/jbc.M113.456947",

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T1 - Homotypic versican G1 domain interactions enhance hyaluronan incorporation into fibrillin microfibrils

AU - Murasawa, Yusuke

AU - Watanabe, Ken

AU - Yoneda, Masahiko

AU - Zako, Masahiro

AU - Kimata, Koji

AU - Sakai, Lynn Y.

AU - Isogai, Zenzo

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Background:Versican interacts with hyaluronan (HA) via its G1 domain and with fibrillin microfibrils via its G3 domain. However, the roles of versican G1 domain-containing fragments (VG1Fs) in the HA-versican-microfibril macrocomplex are not clear. Results:VG1Fs interact homotypically and are recaptured by versican-containing fibrillin microfibrils. Conclusion:Homotypical interactions of VG1Fs enhance HA recruitment to microfibrils. Significance:VG1Fs stabilize HA-versican-microfibril macrocomplexes.

AB - Background:Versican interacts with hyaluronan (HA) via its G1 domain and with fibrillin microfibrils via its G3 domain. However, the roles of versican G1 domain-containing fragments (VG1Fs) in the HA-versican-microfibril macrocomplex are not clear. Results:VG1Fs interact homotypically and are recaptured by versican-containing fibrillin microfibrils. Conclusion:Homotypical interactions of VG1Fs enhance HA recruitment to microfibrils. Significance:VG1Fs stabilize HA-versican-microfibril macrocomplexes.

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Homotypic versican G1 domain interactions enhance hyaluronan incorporation into fibrillin microfibrils

Abstract

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