Homotypic versican G1 domain interactions enhance hyaluronan incorporation into fibrillin microfibrils

Yusuke Murasawa, Ken Watanabe, Masahiko Yoneda, Masahiro Zako, Koji Kimata, Lynn Y. Sakai, Zenzo Isogai

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background:Versican interacts with hyaluronan (HA) via its G1 domain and with fibrillin microfibrils via its G3 domain. However, the roles of versican G1 domain-containing fragments (VG1Fs) in the HA-versican-microfibril macrocomplex are not clear. Results:VG1Fs interact homotypically and are recaptured by versican-containing fibrillin microfibrils. Conclusion:Homotypical interactions of VG1Fs enhance HA recruitment to microfibrils. Significance:VG1Fs stabilize HA-versican-microfibril macrocomplexes.

Original languageEnglish (US)
Pages (from-to)29170-29181
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - Oct 4 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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