TY - JOUR
T1 - Homing Receptors and Metastasis
AU - Sher, Beverly Taylor
AU - Bargatze, Robert
AU - Holzmann, Bernard
AU - Gallatin, W. Michael
AU - Matthews, Dana
AU - Wu, Nora
AU - Picker, Louis
AU - Butcher, Eugene C.
AU - Weissman, Irving L.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - As discussed in the preceding sections, there are several indications that the lymphocyte homing receptors involved in the normal process of lymphocyte recirculation are also relevant to the behavior of metastatic cells. Cell fusion experiments indicate that previously nonmetastatic cells can acquire metastatic capacity from fusion with normal lymphocytes. Murine T lymphomas that bear high levels of functional homing receptors can metastasize to peripheral lymphoid organs, whereas those lymphomas lacking homing receptors cannot. Virtually all lymph node metastases of lymphomas contain a high proportion of MEL-14hi cells, even if the primary tumor has been selected to be relatively deficient in these cells. Further investigations of the biology of lymphocyte homing receptors will reveal whether or not there are additional lymphocyte homing receptors and will clarify the role of lymphocyte homing receptors in metastasis. Antibodies against these lymphocyte homing receptors could therefore be useful for diagnosis and treatment of metastatic disease.
AB - As discussed in the preceding sections, there are several indications that the lymphocyte homing receptors involved in the normal process of lymphocyte recirculation are also relevant to the behavior of metastatic cells. Cell fusion experiments indicate that previously nonmetastatic cells can acquire metastatic capacity from fusion with normal lymphocytes. Murine T lymphomas that bear high levels of functional homing receptors can metastasize to peripheral lymphoid organs, whereas those lymphomas lacking homing receptors cannot. Virtually all lymph node metastases of lymphomas contain a high proportion of MEL-14hi cells, even if the primary tumor has been selected to be relatively deficient in these cells. Further investigations of the biology of lymphocyte homing receptors will reveal whether or not there are additional lymphocyte homing receptors and will clarify the role of lymphocyte homing receptors in metastasis. Antibodies against these lymphocyte homing receptors could therefore be useful for diagnosis and treatment of metastatic disease.
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U2 - 10.1016/S0065-230X(08)60226-2
DO - 10.1016/S0065-230X(08)60226-2
M3 - Article
C2 - 3066147
AN - SCOPUS:0024236910
SN - 0065-230X
VL - 51
SP - 361
EP - 390
JO - Advances in cancer research
JF - Advances in cancer research
IS - C
ER -