Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

Matthew E. Klein; Daniel T. Lioy; Lin Ma; Soren Impey; Gail Mandel; Richard H. Goodman

doi:10.1038/nn2010

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

Matthew E. Klein, Daniel T. Lioy, Lin Ma, Soren Impey, Gail Mandel, Richard H. Goodman

Vollum Institute

Research output: Contribution to journal › Article › peer-review

383 Scopus citations

Abstract

Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.

Original language	English (US)
Pages (from-to)	1513-1514
Number of pages	2
Journal	Nature Neuroscience
Volume	10
Issue number	12
DOIs	https://doi.org/10.1038/nn2010
State	Published - Dec 2007

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nn2010

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title = "Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA",

abstract = "Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.",

author = "Klein, {Matthew E.} and Lioy, {Daniel T.} and Lin Ma and Soren Impey and Gail Mandel and Goodman, {Richard H.}",

note = "Funding Information: We thank Q. Zhang for the experiments examining CtBP. This work was supported by grants from the US National Institutes of Health and the Rett Syndrome Research Foundation.",

year = "2007",

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T1 - Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

AU - Klein, Matthew E.

AU - Lioy, Daniel T.

AU - Ma, Lin

AU - Impey, Soren

AU - Mandel, Gail

AU - Goodman, Richard H.

N1 - Funding Information: We thank Q. Zhang for the experiments examining CtBP. This work was supported by grants from the US National Institutes of Health and the Rett Syndrome Research Foundation.

PY - 2007/12

Y1 - 2007/12

N2 - Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.

AB - Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.

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JF - Nature Neuroscience

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ER -

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

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