Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

Matthew E. Klein, Daniel T. Lioy, Lin Ma, Soren Impey, Gail Mandel, Richard Goodman

Research output: Contribution to journalArticle

338 Scopus citations

Abstract

Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.

Original languageEnglish (US)
Pages (from-to)1513-1514
Number of pages2
JournalNature Neuroscience
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 2007

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ASJC Scopus subject areas

  • Neuroscience(all)

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