Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

Matthew E. Klein, Daniel T. Lioy, Lin Ma, Soren Impey, Gail Mandel, Richard Goodman

Research output: Contribution to journalArticle

334 Citations (Scopus)

Abstract

Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.

Original languageEnglish (US)
Pages (from-to)1513-1514
Number of pages2
JournalNature Neuroscience
Volume10
Issue number12
DOIs
StatePublished - Dec 2007

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Methyl-CpG-Binding Protein 2
MicroRNAs
Brain-Derived Neurotrophic Factor
Protein Biosynthesis
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. / Klein, Matthew E.; Lioy, Daniel T.; Ma, Lin; Impey, Soren; Mandel, Gail; Goodman, Richard.

In: Nature Neuroscience, Vol. 10, No. 12, 12.2007, p. 1513-1514.

Research output: Contribution to journalArticle

Klein, Matthew E. ; Lioy, Daniel T. ; Ma, Lin ; Impey, Soren ; Mandel, Gail ; Goodman, Richard. / Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. In: Nature Neuroscience. 2007 ; Vol. 10, No. 12. pp. 1513-1514.
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