HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen

R. Saenz, C. da Silva Souza, C. T. Huang, M. Larsson, S. Esener, D. Messmer

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

There is a need for new adjuvants that will induce immune responses to subunit vaccines. We show that a short peptide, named Hp91, whose sequence corresponds to an area within the endogenous molecule high mobility group box (HMGB1) protein 1 potentiates cellular immune responses to peptide antigen and cellular and humoral immune responses to protein antigen in vivo. Hp91 promoted the in vivo production of the immunomodulatory cytokines, IFN-γ, TNF-α, IL-6, and IL-12 (p70), as well as antigen-specific activation of CD8+ T cells. These results demonstrate the ability of a short immunostimulatory peptide to serve as an adjuvant for subunit vaccines.

Original languageEnglish (US)
Pages (from-to)7556-7562
Number of pages7
JournalVaccine
Volume28
Issue number47
DOIs
StatePublished - Nov 3 2010

Keywords

  • Adjuvants
  • Dendritic cells
  • HMGB-1 peptides
  • Immunotherapy
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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