HMB-45 Staining in Angiomyolipoma, Cardiac Rhabdomyoma, Other Mesenchymal Processes, and Tuberous Sclerosis-associated Brain Lesions

Douglas Weeks, Donald R. Chase, Richelle Malott, Resa L. Chase, Craig W. Zuppan, J. Bruce Beckwith, Gary W. Mierau

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

HMB-45 monoclonal antibody is thought to be highly specific for melanocytic prolifer ations. In a recent study of two cases of hepatic and one case of renal angiomyolipoma, strong staining of lesional cells with this antibody was unexpectedly encountered. In follow-up evaluation, the authors studied 51 additional soft tissue, renal, and brain tumors and tumor-like processes, with emphasis on those with prominent vascular, myogenous, and fatty components or those known to be associated with tuberous sclerosis. Varying degrees of staining with HMB-45 were seen in 17 of the lesions tested. Strong staining with HMB-45 was demonstrated in four renal angiomyolipo mas. Clearly positive results were also obtained in three other processes associated with the tuberous sclerosis complex, including two cardiac rhabdomyomas and one tuberous lesion of the brain. Weak staining of several other mesenchymal and neural lesions was also observed. Electron microscopic studies showed a spectrum of granules within angiomyolipoma, some of which resembled melanosomes and others renin granules. Similar granules were observed in cardiac rhabdomyoma, cerebral tuberous lesions, and in subependymal giant cell astrocytoma. We propose that tuberous scleros is-associated tumors and tumor-like processes are interrelated, and that these and perhaps other mesenchymal proliferations may share components previously believed to be unique to melanocytic lesions. Int J Surg Pathol 1 (3):191-198, 1994

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalInternational Journal of Surgical Pathology
Volume1
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Rhabdomyoma
Angiomyolipoma
Tuberous Sclerosis
Staining and Labeling
Brain
Kidney
Melanosomes
Neoplasms
Astrocytoma
Renin
Brain Neoplasms
Blood Vessels
Monoclonal Antibodies
Electrons
Antibodies
Liver

Keywords

  • angiomyolipoma
  • electron microscopy
  • HMB-45
  • immunocytochemistry
  • mesen chymal tumors
  • rhabdomyoma
  • tuberous sclerosis

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

HMB-45 Staining in Angiomyolipoma, Cardiac Rhabdomyoma, Other Mesenchymal Processes, and Tuberous Sclerosis-associated Brain Lesions. / Weeks, Douglas; Chase, Donald R.; Malott, Richelle; Chase, Resa L.; Zuppan, Craig W.; Beckwith, J. Bruce; Mierau, Gary W.

In: International Journal of Surgical Pathology, Vol. 1, No. 3, 1994, p. 191-197.

Research output: Contribution to journalArticle

Weeks, Douglas ; Chase, Donald R. ; Malott, Richelle ; Chase, Resa L. ; Zuppan, Craig W. ; Beckwith, J. Bruce ; Mierau, Gary W. / HMB-45 Staining in Angiomyolipoma, Cardiac Rhabdomyoma, Other Mesenchymal Processes, and Tuberous Sclerosis-associated Brain Lesions. In: International Journal of Surgical Pathology. 1994 ; Vol. 1, No. 3. pp. 191-197.
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