HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities

Hongbing Yang, Margarida Rei, Simon Brackenridge, Elena Brenna, Hong Sun, Shaheed Abdulhaqq, Michael K.P. Liu, Weiwei Ma, Prathiba Kurupati, Xiaoning Xu, Vincenzo Cerundolo, Edward Jenkins, Simon J. Davis, Jonah B. Sacha, Klaus Früh, Louis J. Picker, Persephone Borrow, Geraldine M. Gillespie, Andrew J. McMichael

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T cell subsets. Rhesus macaques immunized with a cytomegalovirus-vectored simian immunodeficiency virus (SIV) vaccine generated Mamu-E (HLA-E homolog)-restricted T cell responses that mediated post-challenge SIV replication arrest in >50% of animals. However, HIV-1-specific, HLA-E-restricted T cells have not been observed in HIV-1-infected individuals. Here, HLA-E-restricted, HIV-1-specific CD8 + T cells were primed in vitro. These T cell clones and allogeneic CD8 + T cells transduced with their T cell receptors suppressed HIV-1 replication in CD4 + T cells in vitro. Vaccine induction of efficacious HLA-E-restricted HIV-1-specific T cells should therefore be possible.

Original languageEnglish (US)
JournalScience Immunology
Volume6
Issue number57
DOIs
StatePublished - Mar 25 2021

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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