HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells

Amy S. Heinzel, Jeff E. Grotzke, Rebecca A. Lines, Deborah Lewinsohn, Andria L. McNabb, Daniel Streblow, Veronique M. Brand, Heather J. Grieser, John T. Belisle, David Lewinsohn

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Abstract

Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.

Original languageEnglish (US)
Pages (from-to)1473-1481
Number of pages9
JournalJournal of Experimental Medicine
Volume196
Issue number11
DOIs
StatePublished - Dec 2 2002

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Keywords

  • CD8-positive T lymphocytes
  • HLA-E
  • Human
  • Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Immunology

Cite this

Heinzel, A. S., Grotzke, J. E., Lines, R. A., Lewinsohn, D., McNabb, A. L., Streblow, D., Brand, V. M., Grieser, H. J., Belisle, J. T., & Lewinsohn, D. (2002). HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells. Journal of Experimental Medicine, 196(11), 1473-1481. https://doi.org/10.1084/jem.20020609