HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells

Amy S. Heinzel; Jeff E. Grotzke; Rebecca A. Lines; Deborah A. Lewinsohn; Andria L. McNabb; Daniel N. Streblow; Veronique M. Brand; Heather J. Grieser; John T. Belisle; David M. Lewinsohn

doi:10.1084/jem.20020609

HLA-E-dependent presentation of Mtb-derived antigen to human CD8⁺ T cells

Amy S. Heinzel, Jeff E. Grotzke, Rebecca A. Lines, Deborah A. Lewinsohn, Andria L. McNabb, Daniel N. Streblow, Veronique M. Brand, Heather J. Grieser, John T. Belisle, David M. Lewinsohn

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

Previous studies in mice and humans have suggested an important role for CD8⁺ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8⁺ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8⁺ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.

Original language	English (US)
Pages (from-to)	1473-1481
Number of pages	9
Journal	Journal of Experimental Medicine
Volume	196
Issue number	11
DOIs	https://doi.org/10.1084/jem.20020609
State	Published - Dec 2 2002

Keywords

CD8-positive T lymphocytes
HLA-E
Human
Mycobacterium tuberculosis

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1084/jem.20020609

Cite this

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title = "HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells",

abstract = "Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.",

keywords = "CD8-positive T lymphocytes, HLA-E, Human, Mycobacterium tuberculosis",

author = "Heinzel, {Amy S.} and Grotzke, {Jeff E.} and Lines, {Rebecca A.} and Lewinsohn, {Deborah A.} and McNabb, {Andria L.} and Streblow, {Daniel N.} and Brand, {Veronique M.} and Grieser, {Heather J.} and Belisle, {John T.} and Lewinsohn, {David M.}",

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T1 - HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells

AU - Heinzel, Amy S.

AU - Grotzke, Jeff E.

AU - Lines, Rebecca A.

AU - Lewinsohn, Deborah A.

AU - McNabb, Andria L.

AU - Streblow, Daniel N.

AU - Brand, Veronique M.

AU - Grieser, Heather J.

AU - Belisle, John T.

AU - Lewinsohn, David M.

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AB - Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.

KW - CD8-positive T lymphocytes

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KW - Mycobacterium tuberculosis

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