HLA-DR expression by platelets in acute idiopathic thrombocytopenic purpura

Lynn Boshkov, J. G. Kelton, P. F. Halloran

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Induction of expression of MHC class II antigens on the surface of cells that do not ordinarily express these proteins has been implicated in the pathogenesis of autoimmunity in diabetes mellitus and autoimmune thyroiditis. Platelets express class I but not class II HLA antigens. In this report, we describe a child with acute idiopathic thrombocytopenic purpura who at the time of the thrombocytopenic episode had class II (HLA-DR) antigens on his platelets. Following recovery, the HLA-DR antigens were no longer present on the platelets. We postulated that class II had been induced on his megakaryocytes by a cytokine such as interferon gamma, and that the induced expression of class II antigens contributed to the autoimmune disorder. To substantiate this possibility we next studied class I and II antigen expression on an erythroleukaemia cell line (HEL), which has many megakaryocytic features. Following treatment of HEL cells with interferon gamma, class I expression was increased and HLA-DR antigens were induced. These observations suggest that cytokine-mediated induced HLA-DR expression may contribute to the pathogenesis of a subset of thrombocytopenias.

Original languageEnglish (US)
Pages (from-to)552-557
Number of pages6
JournalBritish Journal of Haematology
Volume81
Issue number4
StatePublished - 1992

Fingerprint

Idiopathic Thrombocytopenic Purpura
Histocompatibility Antigens Class II
HLA-DR Antigens
Blood Platelets
Interferon-gamma
Cytokines
Autoimmune Thyroiditis
Leukemia, Erythroblastic, Acute
Histocompatibility Antigens Class I
Megakaryocytes
HLA Antigens
Autoimmunity
Diabetes Mellitus
Cell Line
Proteins
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Boshkov, L., Kelton, J. G., & Halloran, P. F. (1992). HLA-DR expression by platelets in acute idiopathic thrombocytopenic purpura. British Journal of Haematology, 81(4), 552-557.

HLA-DR expression by platelets in acute idiopathic thrombocytopenic purpura. / Boshkov, Lynn; Kelton, J. G.; Halloran, P. F.

In: British Journal of Haematology, Vol. 81, No. 4, 1992, p. 552-557.

Research output: Contribution to journalArticle

Boshkov, L, Kelton, JG & Halloran, PF 1992, 'HLA-DR expression by platelets in acute idiopathic thrombocytopenic purpura', British Journal of Haematology, vol. 81, no. 4, pp. 552-557.
Boshkov, Lynn ; Kelton, J. G. ; Halloran, P. F. / HLA-DR expression by platelets in acute idiopathic thrombocytopenic purpura. In: British Journal of Haematology. 1992 ; Vol. 81, No. 4. pp. 552-557.
@article{de1c02a97f8748d6947176924cb3b75a,
title = "HLA-DR expression by platelets in acute idiopathic thrombocytopenic purpura",
abstract = "Induction of expression of MHC class II antigens on the surface of cells that do not ordinarily express these proteins has been implicated in the pathogenesis of autoimmunity in diabetes mellitus and autoimmune thyroiditis. Platelets express class I but not class II HLA antigens. In this report, we describe a child with acute idiopathic thrombocytopenic purpura who at the time of the thrombocytopenic episode had class II (HLA-DR) antigens on his platelets. Following recovery, the HLA-DR antigens were no longer present on the platelets. We postulated that class II had been induced on his megakaryocytes by a cytokine such as interferon gamma, and that the induced expression of class II antigens contributed to the autoimmune disorder. To substantiate this possibility we next studied class I and II antigen expression on an erythroleukaemia cell line (HEL), which has many megakaryocytic features. Following treatment of HEL cells with interferon gamma, class I expression was increased and HLA-DR antigens were induced. These observations suggest that cytokine-mediated induced HLA-DR expression may contribute to the pathogenesis of a subset of thrombocytopenias.",
author = "Lynn Boshkov and Kelton, {J. G.} and Halloran, {P. F.}",
year = "1992",
language = "English (US)",
volume = "81",
pages = "552--557",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - HLA-DR expression by platelets in acute idiopathic thrombocytopenic purpura

AU - Boshkov, Lynn

AU - Kelton, J. G.

AU - Halloran, P. F.

PY - 1992

Y1 - 1992

N2 - Induction of expression of MHC class II antigens on the surface of cells that do not ordinarily express these proteins has been implicated in the pathogenesis of autoimmunity in diabetes mellitus and autoimmune thyroiditis. Platelets express class I but not class II HLA antigens. In this report, we describe a child with acute idiopathic thrombocytopenic purpura who at the time of the thrombocytopenic episode had class II (HLA-DR) antigens on his platelets. Following recovery, the HLA-DR antigens were no longer present on the platelets. We postulated that class II had been induced on his megakaryocytes by a cytokine such as interferon gamma, and that the induced expression of class II antigens contributed to the autoimmune disorder. To substantiate this possibility we next studied class I and II antigen expression on an erythroleukaemia cell line (HEL), which has many megakaryocytic features. Following treatment of HEL cells with interferon gamma, class I expression was increased and HLA-DR antigens were induced. These observations suggest that cytokine-mediated induced HLA-DR expression may contribute to the pathogenesis of a subset of thrombocytopenias.

AB - Induction of expression of MHC class II antigens on the surface of cells that do not ordinarily express these proteins has been implicated in the pathogenesis of autoimmunity in diabetes mellitus and autoimmune thyroiditis. Platelets express class I but not class II HLA antigens. In this report, we describe a child with acute idiopathic thrombocytopenic purpura who at the time of the thrombocytopenic episode had class II (HLA-DR) antigens on his platelets. Following recovery, the HLA-DR antigens were no longer present on the platelets. We postulated that class II had been induced on his megakaryocytes by a cytokine such as interferon gamma, and that the induced expression of class II antigens contributed to the autoimmune disorder. To substantiate this possibility we next studied class I and II antigen expression on an erythroleukaemia cell line (HEL), which has many megakaryocytic features. Following treatment of HEL cells with interferon gamma, class I expression was increased and HLA-DR antigens were induced. These observations suggest that cytokine-mediated induced HLA-DR expression may contribute to the pathogenesis of a subset of thrombocytopenias.

UR - http://www.scopus.com/inward/record.url?scp=0026765012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026765012&partnerID=8YFLogxK

M3 - Article

VL - 81

SP - 552

EP - 557

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 4

ER -