HLA alleles and risk of cervical intraepithelial neoplasia among Southwestern American Indian Women

Melissa A. Schiff, Raymond J. Apple, Patricia Lin, J. Lee Nelson, Cosette M. Wheeler, Thomas M. Becker

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

An increase in cervical intraepithelial neoplasia (CIN) has been described in American Indian women in New Mexico. Differences in human leukocyte antigen (HLA) alleles have been reported in cervical intraepithelial neoplasia (CIN) compared with controls in other populations. We investigated HLA alleles and CIN in Southwest American Indian women. The case control study included 89 women with biopsy-proven CIN II/III (diagnosed November 1994 through October 1997) and 271 similar women with normal cervical epithelium from the same clinics. DRB1, DQB1, and DPB1 alleles were determined using DNA typing techniques. DQA1 and HLA-A allele typing was included for some subjects (randomly chosen n = 37 and n = 163 cases and controls, respectively). We found a decreased risk of CIN with DRB1*1402 (OR 0.5, 95% CI 0.3-0.9) and an increased risk with DRB1*1501 (OR 2.7, 95% CI 0.9-7.3). Additionally, DQA1*0102 was associated with increased risk (OR 4.5, 95% CI 1.3-5.3) and HLA-A*02 with decreased risk (OR 0.4, CI 0.2-0.9). Our findings are discussed along with studies in other populations.

Original languageEnglish (US)
Pages (from-to)1050-1056
Number of pages7
JournalHuman Immunology
Volume66
Issue number10
DOIs
StatePublished - Oct 1 2005

Keywords

  • Cervical intraepithelial neoplasia
  • HLA alleles
  • Indians, North American

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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