TY - JOUR
T1 - HLA-A2, or a closely linked gene, confers susceptibility to early-onset sporadic alzheimer’s disease in mene
AU - Payami, Haydeh
AU - Kaye, J.
AU - Becker, W.
AU - Norman, D.
AU - Wetzsteon, P.
PY - 1991/10
Y1 - 1991/10
N2 - There is a weak association between Alzheimer’s disease (AD) and the histocompatibility antigen HLA-A2, suggesting that A2 has either a minor role in AD or a major role in a subtype of it. To test these alternatives, we studied 54 consecutively ascertained AD patients diagnosed by NINCDS-ADRDA criteria. Patients had a higher frequency of A2 than control subjects, primarily due to the elevated frequency of this antigen in men with early onset of dementia (< 60 years): 92% of early-onset men had A2 as compared with 44% of controls. This finding suggests that A2, or a closely linked gene, confers susceptibility to early-onset AD in men. Furthermore, A2 appears to be primarily associated with sporadic AD, rather than with the familial subtype.
AB - There is a weak association between Alzheimer’s disease (AD) and the histocompatibility antigen HLA-A2, suggesting that A2 has either a minor role in AD or a major role in a subtype of it. To test these alternatives, we studied 54 consecutively ascertained AD patients diagnosed by NINCDS-ADRDA criteria. Patients had a higher frequency of A2 than control subjects, primarily due to the elevated frequency of this antigen in men with early onset of dementia (< 60 years): 92% of early-onset men had A2 as compared with 44% of controls. This finding suggests that A2, or a closely linked gene, confers susceptibility to early-onset AD in men. Furthermore, A2 appears to be primarily associated with sporadic AD, rather than with the familial subtype.
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U2 - 10.1212/wnl.41.10.1544
DO - 10.1212/wnl.41.10.1544
M3 - Article
C2 - 1922793
AN - SCOPUS:0026062664
SN - 0028-3878
VL - 41
SP - 1544
EP - 1548
JO - Neurology
JF - Neurology
IS - 10
ER -