HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease

S. Zareparsi, D. M. James, Jeffrey Kaye, T. D. Bird, G. D. Schellenberg, H. Payami

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22 Scopus citations

Abstract

AD is associated with the A2 allele of the human leukocyte antigen (HLA). However, it is not currently known whether there is any difference between A2 homozygotes and A2 heterozygotes. The authors studied 458 patients with AD and found that A2 homozygotes had earlier onset of AD than either A2 heterozygotes (5.4 years, p = 0.002) or those without A2 (5.2 years, p = 0.003). The "recessive" nature of this association suggests that loss of function at the HLA-A locus or a closely linked gene is associated with AD.

Original languageEnglish (US)
Pages (from-to)973-975
Number of pages3
JournalNeurology
Volume58
Issue number6
Publication statusPublished - Mar 26 2002

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Zareparsi, S., James, D. M., Kaye, J., Bird, T. D., Schellenberg, G. D., & Payami, H. (2002). HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease. Neurology, 58(6), 973-975.