HIV therapy simulator: A graphical user interface for comparing the effectiveness of novel therapy regimens

Huat Chye Lim, Marcel Curlin, John E. Mittler

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Computer simulation models can be useful in exploring the efficacy of HIV therapy regimens in preventing the evolution of drug-resistant viruses. Current modeling programs, however, were designed by researchers with expertise in computational biology, limiting their accessibility to those who might lack such a background. We have developed a user-friendly graphical program, HIV Therapy Simulator (HIVSIM), that is accessible to nontechnical users. The program allows clinicians and researchers to explore the effectiveness of various therapeutic strategies, such as structured treatment interruptions, booster therapies and inductionmaintenance therapies. We anticipate that HIVSIM will be useful for evaluating novel drug-based treatment concepts in clinical research, and as an educational tool.

Original languageEnglish (US)
Article numberbtr515
Pages (from-to)3065-3066
Number of pages2
JournalBioinformatics
Volume27
Issue number21
DOIs
Publication statusPublished - Nov 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability
  • Medicine(all)

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