HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells

Mohamed Elrefaei, Florence L. Ventura, Chris A R Baker, Richard Clark, David Bangsberg, Huyen Cao

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

IL-10 producing T cells inhibit Ag-specific CD8+ T cell responses and may play a role in the immune dysregulation observed in HIV infection. We have previously observed the presence of HIV-specific IL-10-positive CD8+ T cells in advanced HIV disease. In this study, we examined the suppressive function of the Gag-specific IL-10-positive CD8 + T cells. Removal of these IL-10-positive CD8+ T cells resulted in increased cytolysis and IL-2, but not IFN-γ, production by both HIV- and human CMV-specific CD8+ T cells. In addition, these IL-10-positive CD8+ T cells mediated suppression through direct cell-cell contact, and had a distinct immunophenotypic profile compared with other regulatory T cells. We describe a new suppressor CD8+ T cell population in advanced HIV infection that may contribute to the immune dysfunction, observed in HIV infection.

Original languageEnglish (US)
Pages (from-to)3265-3271
Number of pages7
JournalJournal of Immunology
Volume178
Issue number5
StatePublished - Mar 1 2007
Externally publishedYes

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Interleukin-10
Interleukin-2
HIV
T-Lymphocytes
HIV Infections
Regulatory T-Lymphocytes
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Elrefaei, M., Ventura, F. L., Baker, C. A. R., Clark, R., Bangsberg, D., & Cao, H. (2007). HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells. Journal of Immunology, 178(5), 3265-3271.

HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells. / Elrefaei, Mohamed; Ventura, Florence L.; Baker, Chris A R; Clark, Richard; Bangsberg, David; Cao, Huyen.

In: Journal of Immunology, Vol. 178, No. 5, 01.03.2007, p. 3265-3271.

Research output: Contribution to journalArticle

Elrefaei, M, Ventura, FL, Baker, CAR, Clark, R, Bangsberg, D & Cao, H 2007, 'HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells', Journal of Immunology, vol. 178, no. 5, pp. 3265-3271.
Elrefaei, Mohamed ; Ventura, Florence L. ; Baker, Chris A R ; Clark, Richard ; Bangsberg, David ; Cao, Huyen. / HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells. In: Journal of Immunology. 2007 ; Vol. 178, No. 5. pp. 3265-3271.
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