TY - JOUR
T1 - HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells
AU - Elrefaei, Mohamed
AU - Ventura, Florence L.
AU - Baker, Chris A.R.
AU - Clark, Richard
AU - Bangsberg, David R.
AU - Cao, Huyen
PY - 2007/3/1
Y1 - 2007/3/1
N2 - IL-10 producing T cells inhibit Ag-specific CD8+ T cell responses and may play a role in the immune dysregulation observed in HIV infection. We have previously observed the presence of HIV-specific IL-10-positive CD8+ T cells in advanced HIV disease. In this study, we examined the suppressive function of the Gag-specific IL-10-positive CD8 + T cells. Removal of these IL-10-positive CD8+ T cells resulted in increased cytolysis and IL-2, but not IFN-γ, production by both HIV- and human CMV-specific CD8+ T cells. In addition, these IL-10-positive CD8+ T cells mediated suppression through direct cell-cell contact, and had a distinct immunophenotypic profile compared with other regulatory T cells. We describe a new suppressor CD8+ T cell population in advanced HIV infection that may contribute to the immune dysfunction, observed in HIV infection.
AB - IL-10 producing T cells inhibit Ag-specific CD8+ T cell responses and may play a role in the immune dysregulation observed in HIV infection. We have previously observed the presence of HIV-specific IL-10-positive CD8+ T cells in advanced HIV disease. In this study, we examined the suppressive function of the Gag-specific IL-10-positive CD8 + T cells. Removal of these IL-10-positive CD8+ T cells resulted in increased cytolysis and IL-2, but not IFN-γ, production by both HIV- and human CMV-specific CD8+ T cells. In addition, these IL-10-positive CD8+ T cells mediated suppression through direct cell-cell contact, and had a distinct immunophenotypic profile compared with other regulatory T cells. We describe a new suppressor CD8+ T cell population in advanced HIV infection that may contribute to the immune dysfunction, observed in HIV infection.
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U2 - 10.4049/jimmunol.178.5.3265
DO - 10.4049/jimmunol.178.5.3265
M3 - Article
C2 - 17312176
AN - SCOPUS:33847412075
SN - 0022-1767
VL - 178
SP - 3265
EP - 3271
JO - Journal of Immunology
JF - Journal of Immunology
IS - 5
ER -