HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda

Mark J. Siedner, June Ho Kim, Ruth Sentongo Nakku, Linda Hemphill, Virginia A. Triant, Jessica E. Haberer, Jeffrey N. Martin, Yap Boum, Douglas S. Kwon, Alexander C. Tsai, Peter W. Hunt, Samson Okello, David R. Bangsberg

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

HIV infection is associated with arterial stiffness, but no studies have assessed this relationship in sub-Saharan Africa. We enrolled 205 participants over 40 years old in Uganda: 105 on antiretroviral therapy for a median of 7 years, and a random sample of 100 age and sex-matched HIV-uninfected controls from the clinic catchment area. The prevalence of arterial stiffness (ankle brachial index >1.2) was 33%, 18%, 19% and 2% in HIV+ men, HIV-men, HIV+ women, and HIV-women. In multivariable models adjusted for cardiovascular risk factors, HIV+ individuals had over double the prevalence of arterial stiffness (adjusted prevalence ratio 2.86, 95% confidence interval 1.41-5.79, P=0.003).

Original languageEnglish (US)
Pages (from-to)667-670
Number of pages4
JournalAIDS
Volume30
Issue number4
DOIs
StatePublished - Feb 20 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Siedner, M. J., Kim, J. H., Nakku, R. S., Hemphill, L., Triant, V. A., Haberer, J. E., Martin, J. N., Boum, Y., Kwon, D. S., Tsai, A. C., Hunt, P. W., Okello, S., & Bangsberg, D. R. (2016). HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda. AIDS, 30(4), 667-670. https://doi.org/10.1097/QAD.0000000000000992