HIV and HCMV coinfect brain cells in patients with AIDS

Jay Nelson, Catherine Reynolds-Kohler, Michael B A Oldstone, Clayton A. Wiley

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Direct interactions at the cellular level in vitro have been reported which suggest that opportunistic viruses may reactivate latent human immunodeficiency virus (HIV) in cells. The significance of these findings depends on whether coinfection of the same cell with these two different types of viruses occurs in vivo. Using various double-labeling techniques, we present evidence that human cytomegalovirus (HCMV) and HIV can coinfect the same cell in vivo in central nervous system tissue from AIDS patients. These observations indicate that direct cooperation at the single cell level could occur between HCMV and HIV. This new finding in the context of reports that herpesviruses can increase HIV transcription in vitro, suggest the possibility of a direct role for herpesviruses in the pathogenesis of AIDS.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalVirology
Volume165
Issue number1
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Cytomegalovirus
Acquired Immunodeficiency Syndrome
HIV
Herpesviridae
Brain
Viruses
Nerve Tissue
Coinfection
Central Nervous System
In Vitro Techniques

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Nelson, J., Reynolds-Kohler, C., Oldstone, M. B. A., & Wiley, C. A. (1988). HIV and HCMV coinfect brain cells in patients with AIDS. Virology, 165(1), 286-290. https://doi.org/10.1016/0042-6822(88)90685-X

HIV and HCMV coinfect brain cells in patients with AIDS. / Nelson, Jay; Reynolds-Kohler, Catherine; Oldstone, Michael B A; Wiley, Clayton A.

In: Virology, Vol. 165, No. 1, 1988, p. 286-290.

Research output: Contribution to journalArticle

Nelson, J, Reynolds-Kohler, C, Oldstone, MBA & Wiley, CA 1988, 'HIV and HCMV coinfect brain cells in patients with AIDS', Virology, vol. 165, no. 1, pp. 286-290. https://doi.org/10.1016/0042-6822(88)90685-X
Nelson, Jay ; Reynolds-Kohler, Catherine ; Oldstone, Michael B A ; Wiley, Clayton A. / HIV and HCMV coinfect brain cells in patients with AIDS. In: Virology. 1988 ; Vol. 165, No. 1. pp. 286-290.
@article{63712a6c3a9247538d78a04d9f55bd78,
title = "HIV and HCMV coinfect brain cells in patients with AIDS",
abstract = "Direct interactions at the cellular level in vitro have been reported which suggest that opportunistic viruses may reactivate latent human immunodeficiency virus (HIV) in cells. The significance of these findings depends on whether coinfection of the same cell with these two different types of viruses occurs in vivo. Using various double-labeling techniques, we present evidence that human cytomegalovirus (HCMV) and HIV can coinfect the same cell in vivo in central nervous system tissue from AIDS patients. These observations indicate that direct cooperation at the single cell level could occur between HCMV and HIV. This new finding in the context of reports that herpesviruses can increase HIV transcription in vitro, suggest the possibility of a direct role for herpesviruses in the pathogenesis of AIDS.",
author = "Jay Nelson and Catherine Reynolds-Kohler and Oldstone, {Michael B A} and Wiley, {Clayton A.}",
year = "1988",
doi = "10.1016/0042-6822(88)90685-X",
language = "English (US)",
volume = "165",
pages = "286--290",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - HIV and HCMV coinfect brain cells in patients with AIDS

AU - Nelson, Jay

AU - Reynolds-Kohler, Catherine

AU - Oldstone, Michael B A

AU - Wiley, Clayton A.

PY - 1988

Y1 - 1988

N2 - Direct interactions at the cellular level in vitro have been reported which suggest that opportunistic viruses may reactivate latent human immunodeficiency virus (HIV) in cells. The significance of these findings depends on whether coinfection of the same cell with these two different types of viruses occurs in vivo. Using various double-labeling techniques, we present evidence that human cytomegalovirus (HCMV) and HIV can coinfect the same cell in vivo in central nervous system tissue from AIDS patients. These observations indicate that direct cooperation at the single cell level could occur between HCMV and HIV. This new finding in the context of reports that herpesviruses can increase HIV transcription in vitro, suggest the possibility of a direct role for herpesviruses in the pathogenesis of AIDS.

AB - Direct interactions at the cellular level in vitro have been reported which suggest that opportunistic viruses may reactivate latent human immunodeficiency virus (HIV) in cells. The significance of these findings depends on whether coinfection of the same cell with these two different types of viruses occurs in vivo. Using various double-labeling techniques, we present evidence that human cytomegalovirus (HCMV) and HIV can coinfect the same cell in vivo in central nervous system tissue from AIDS patients. These observations indicate that direct cooperation at the single cell level could occur between HCMV and HIV. This new finding in the context of reports that herpesviruses can increase HIV transcription in vitro, suggest the possibility of a direct role for herpesviruses in the pathogenesis of AIDS.

UR - http://www.scopus.com/inward/record.url?scp=0023795274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023795274&partnerID=8YFLogxK

U2 - 10.1016/0042-6822(88)90685-X

DO - 10.1016/0042-6822(88)90685-X

M3 - Article

C2 - 2838967

AN - SCOPUS:0023795274

VL - 165

SP - 286

EP - 290

JO - Virology

JF - Virology

SN - 0042-6822

IS - 1

ER -