TY - JOUR
T1 - HIV and HCMV coinfect brain cells in patients with AIDS
AU - Nelson, Jay A.
AU - Reynolds-Kohler, Catherine
AU - Oldstone, Michael B.A.
AU - Wiley, Clayton A.
N1 - Funding Information:
We thank Drs . Kathy Shriver and Lynn Goldstein, Genetic Sys- tems, Inc ., Seattle, WA, for their generous gift of the mouse monoclonal antibody directed against the HIV gp4l membrane . We also thank Drs . Floyd Bloom, John Gnann, and Rachel Schrier for critical comments on this manuscript, and Patrick Burrola and Nancy Keat-ing for invaluable technical assistance on this paper . This work was supported by grants from the University of California AIDS Task Force to J .A .N . and C .A .W . J .A .N . is a recipient of Junior Faculty Award from the American Cancer Society . C .A .W . is a recipient of a University of California Academic Senate Award and a Teacher Investigator Development Award from NIH NINCDS . Work in part was supported by a US Public Health Service Grant .
PY - 1988/7
Y1 - 1988/7
N2 - Direct interactions at the cellular level in vitro have been reported which suggest that opportunistic viruses may reactivate latent human immunodeficiency virus (HIV) in cells. The significance of these findings depends on whether coinfection of the same cell with these two different types of viruses occurs in vivo. Using various double-labeling techniques, we present evidence that human cytomegalovirus (HCMV) and HIV can coinfect the same cell in vivo in central nervous system tissue from AIDS patients. These observations indicate that direct cooperation at the single cell level could occur between HCMV and HIV. This new finding in the context of reports that herpesviruses can increase HIV transcription in vitro, suggest the possibility of a direct role for herpesviruses in the pathogenesis of AIDS.
AB - Direct interactions at the cellular level in vitro have been reported which suggest that opportunistic viruses may reactivate latent human immunodeficiency virus (HIV) in cells. The significance of these findings depends on whether coinfection of the same cell with these two different types of viruses occurs in vivo. Using various double-labeling techniques, we present evidence that human cytomegalovirus (HCMV) and HIV can coinfect the same cell in vivo in central nervous system tissue from AIDS patients. These observations indicate that direct cooperation at the single cell level could occur between HCMV and HIV. This new finding in the context of reports that herpesviruses can increase HIV transcription in vitro, suggest the possibility of a direct role for herpesviruses in the pathogenesis of AIDS.
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U2 - 10.1016/0042-6822(88)90685-X
DO - 10.1016/0042-6822(88)90685-X
M3 - Article
C2 - 2838967
AN - SCOPUS:0023795274
SN - 0042-6822
VL - 165
SP - 286
EP - 290
JO - Virology
JF - Virology
IS - 1
ER -