HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas

Ashlee Moses, Sally E. Williams, Joanne G. Strussenberg, Marika L. Heneveld, Rebecca A. Ruhl, Antony C. Bakke, Grover C. Bagby, Jay Nelson

Research output: Contribution to journalArticle

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Abstract

Human immunodeficiency virus (HIV)-1 infection is associated with the development of aggressive extranodal B-cell non-Hodgkin's lymphomas. Using microvascular endothelial cell (MVEC)-enriched bone marrow stromal cultures, HIV infection of stromal MVECs from lymphoma patients induced the outgrowth of malignant B cells. MVECs were the only HIV-infected cells in the stroma, and purified brain MVECs also induced a phenotype supportive of neoplastic B- cell attachment and proliferation. HIV infection of MVECs stimulated surface expression of CD40 and allowed preferential induction of the vascular cell adhesion molecule VCAM-1 after CD40 triggering. B-lymphoma cells expressed the CD40 ligand (CD40L), and blocking of CD40-CD40L interactions between HIV- infected MVECs and B-lymphoma cells inhibited B-cell attachment and proliferation. These observations suggest that HIV promotes B-lymphoma cell growth through facilitating attachment of lymphoma cells to HIV-infected MVECs and represent a novel mechanism through which viruses may induce malignancies.

Original languageEnglish (US)
Pages (from-to)1242-1249
Number of pages8
JournalNature Medicine
Volume3
Issue number11
StatePublished - Nov 1997

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AIDS-Related Lymphoma
Virus Activation
Endothelial cells
B-Cell Lymphoma
Viruses
HIV-1
Endothelial Cells
Cells
HIV
Virus Diseases
CD40 Ligand
B-Lymphocytes
Vascular Cell Adhesion Molecule-1
Lymphoma
Cell Proliferation
Non-Hodgkin's Lymphoma
Cell growth
Bone Marrow
Cell culture
Phenotype

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Moses, A., Williams, S. E., Strussenberg, J. G., Heneveld, M. L., Ruhl, R. A., Bakke, A. C., ... Nelson, J. (1997). HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas. Nature Medicine, 3(11), 1242-1249.

HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas. / Moses, Ashlee; Williams, Sally E.; Strussenberg, Joanne G.; Heneveld, Marika L.; Ruhl, Rebecca A.; Bakke, Antony C.; Bagby, Grover C.; Nelson, Jay.

In: Nature Medicine, Vol. 3, No. 11, 11.1997, p. 1242-1249.

Research output: Contribution to journalArticle

Moses, A, Williams, SE, Strussenberg, JG, Heneveld, ML, Ruhl, RA, Bakke, AC, Bagby, GC & Nelson, J 1997, 'HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas', Nature Medicine, vol. 3, no. 11, pp. 1242-1249.
Moses A, Williams SE, Strussenberg JG, Heneveld ML, Ruhl RA, Bakke AC et al. HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas. Nature Medicine. 1997 Nov;3(11):1242-1249.
Moses, Ashlee ; Williams, Sally E. ; Strussenberg, Joanne G. ; Heneveld, Marika L. ; Ruhl, Rebecca A. ; Bakke, Antony C. ; Bagby, Grover C. ; Nelson, Jay. / HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas. In: Nature Medicine. 1997 ; Vol. 3, No. 11. pp. 1242-1249.
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