HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses

S. H. Lewis, H. E. Fox, S. H. Lewis, S. H. Lewis, C. Reynolds-Kohler, J. A. Nelson

Research output: Contribution to journalArticle

202 Scopus citations

Abstract

AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age.

Original languageEnglish (US)
Pages (from-to)565-568
Number of pages4
JournalThe Lancet
Volume335
Issue number8689
DOIs
StatePublished - Mar 10 1990

ASJC Scopus subject areas

  • Medicine(all)

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