HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses

S. H. Lewis; H. E. Fox; S. H. Lewis; S. H. Lewis; C. Reynolds-Kohler; J. A. Nelson

doi:10.1016/0140-6736(90)90349-A

HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses

S. H. Lewis, H. E. Fox, S. H. Lewis, S. H. Lewis, C. Reynolds-Kohler, J. A. Nelson

Research output: Contribution to journal › Article › peer-review

224 Scopus citations

Abstract

AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age.

Original language	English (US)
Pages (from-to)	565-568
Number of pages	4
Journal	The Lancet
Volume	335
Issue number	8689
DOIs	https://doi.org/10.1016/0140-6736(90)90349-A
State	Published - Mar 10 1990
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1016/0140-6736(90)90349-A

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title = "HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses",

abstract = "AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age.",

author = "Lewis, {S. H.} and Fox, {H. E.} and Lewis, {S. H.} and Lewis, {S. H.} and C. Reynolds-Kohler and Nelson, {J. A.}",

note = "Funding Information: This work was supported by USPHS, the University of California Task Force on AIDS (J. A. N.), the American Cancer Society (S. H. L.), and a faculty award from the American Cancer Society (J. A. N.). We thank Drs",

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doi = "10.1016/0140-6736(90)90349-A",

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pages = "565--568",

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T1 - HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses

AU - Lewis, S. H.

AU - Fox, H. E.

AU - Lewis, S. H.

AU - Reynolds-Kohler, C.

AU - Nelson, J. A.

N1 - Funding Information: This work was supported by USPHS, the University of California Task Force on AIDS (J. A. N.), the American Cancer Society (S. H. L.), and a faculty award from the American Cancer Society (J. A. N.). We thank Drs

PY - 1990/3/10

Y1 - 1990/3/10

N2 - AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age.

AB - AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age.

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HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses

Abstract

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