Historic Review of Retinoblastoma

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Retinoblastoma was first described as a specific entity by James Wardrop in 1809, with enucleation as his suggested treatment. Histologic studies including those of Flexner and Verhoeff and subsequent electron microscopy have given insights into its pathogenesis. The establishment of cell lines of retinoblastoma, the “nude” mouse model, and other animal models have contributed additional information. Classic genetic and epidemiologic studies have led to a broad and intense interest in the tumor despite its relative infrequency. Attempts now in progress to identify and characterize the oncogene for retinoblastoma may prove to be the most exciting part of the history of retinoblastoma.

Original languageEnglish (US)
Pages (from-to)654-662
Number of pages9
Issue number6
StatePublished - Jan 1 1987
Externally publishedYes


  • medical history
  • retinoblastoma

ASJC Scopus subject areas

  • Ophthalmology


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