Histone deacetylase inhibitors in cancer therapy

Min Jung Lee, Yeong Sang Kim, Shivaani Kummar, Giuseppe Giaccone, Jane B. Trepel

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations

Abstract

Purpose of review The purpose of this review is to provide an overview of recent advances in the development of histone deacetylase inhibitors (HDACi) for the treatment of cancer. Recent findings Recently, there has been a dramatic expansion of HDACi clinical investigation. There are now 11 HDACi in clinical trial, including inhibitors with a broad spectrum of HDAC isoform inhibitory activity as well as drugs with isoform selectivity. Over 70 combination therapy trials are in progress. Major areas of progress covered include the entry of new HDAC inhibitors into clinical development, recent progress in understanding of molecular mechanisms of HDACi anticancer activity, and a preclinical and clinical update on HDACi in combination. Summary In the period under review there have been advances in understanding of HDACi mechanisms of action, identification of rational combinations that address increased efficacy and overcoming resistance, and greatly expanded clinical development of pan-HDAC-inhibitory and isoform-selective inhibitors in monotherapy and combination therapy protocols.

Original languageEnglish (US)
Pages (from-to)639-649
Number of pages11
JournalCurrent Opinion in Oncology
Volume20
Issue number6
DOIs
StatePublished - Nov 2008
Externally publishedYes

Keywords

  • Cancer therapy
  • Clinical trial
  • Combination therapy
  • Histone deacetylase inhibitors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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