Histologic and receptor analysis of primary and secondary vestibulodynia and controls: a prospective study

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Abstract

Objective: The objective of the study was to assess the association between hormone receptor densities, pain nerves, and inflammation in vestibulodynia patients. Study Design: In a prospective study, tender and nontender biopsies from 10 primary and 10 secondary vestibulodynia patients were compared with biopsies in 4 nontender controls. Hormone receptors were evaluated using immunohistochemistry for estrogen receptor-α and -β, androgen, and progesterone receptors. Inflammation, nerves, and mast cells were assessed histologically. Statistical analysis was by Fisher's exact test, analysis of variance, paired Student t test, and Wilcoxon rank test. Results: Tender sites from primary vestibulodynia had increased nerve density compared with secondary and control biopsies (P = .01). Tender sites in secondary vestibulodynia had more lymphocytes than tender primary sites and control biopsies (P <.0001). Mast cells were increased in tender sites compared with nontender and controls. There were no differences in hormone receptor expression. Conclusion: Markers of inflammation differed between primary and secondary vestibulodynia and controls.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume202
Issue number6
DOIs
StatePublished - Jun 2010

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Vulvodynia
Prospective Studies
Biopsy
Hormones
Inflammation
Mast Cells
Nociceptors
Androgen Receptors
Neuralgia
Progesterone Receptors
Nonparametric Statistics
Estrogen Receptors
Analysis of Variance
Immunohistochemistry
Lymphocytes
Students
Neurons

Keywords

  • inflammation and steroid receptors
  • primary and secondary vestibulodynia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

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title = "Histologic and receptor analysis of primary and secondary vestibulodynia and controls: a prospective study",
abstract = "Objective: The objective of the study was to assess the association between hormone receptor densities, pain nerves, and inflammation in vestibulodynia patients. Study Design: In a prospective study, tender and nontender biopsies from 10 primary and 10 secondary vestibulodynia patients were compared with biopsies in 4 nontender controls. Hormone receptors were evaluated using immunohistochemistry for estrogen receptor-α and -β, androgen, and progesterone receptors. Inflammation, nerves, and mast cells were assessed histologically. Statistical analysis was by Fisher's exact test, analysis of variance, paired Student t test, and Wilcoxon rank test. Results: Tender sites from primary vestibulodynia had increased nerve density compared with secondary and control biopsies (P = .01). Tender sites in secondary vestibulodynia had more lymphocytes than tender primary sites and control biopsies (P <.0001). Mast cells were increased in tender sites compared with nontender and controls. There were no differences in hormone receptor expression. Conclusion: Markers of inflammation differed between primary and secondary vestibulodynia and controls.",
keywords = "inflammation and steroid receptors, primary and secondary vestibulodynia",
author = "Martha Goetsch and Terry Morgan and Veselina Korcheva and Hong Li and Dawn Peters and Catherine Leclair",
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AU - Goetsch, Martha

AU - Morgan, Terry

AU - Korcheva, Veselina

AU - Li, Hong

AU - Peters, Dawn

AU - Leclair, Catherine

PY - 2010/6

Y1 - 2010/6

N2 - Objective: The objective of the study was to assess the association between hormone receptor densities, pain nerves, and inflammation in vestibulodynia patients. Study Design: In a prospective study, tender and nontender biopsies from 10 primary and 10 secondary vestibulodynia patients were compared with biopsies in 4 nontender controls. Hormone receptors were evaluated using immunohistochemistry for estrogen receptor-α and -β, androgen, and progesterone receptors. Inflammation, nerves, and mast cells were assessed histologically. Statistical analysis was by Fisher's exact test, analysis of variance, paired Student t test, and Wilcoxon rank test. Results: Tender sites from primary vestibulodynia had increased nerve density compared with secondary and control biopsies (P = .01). Tender sites in secondary vestibulodynia had more lymphocytes than tender primary sites and control biopsies (P <.0001). Mast cells were increased in tender sites compared with nontender and controls. There were no differences in hormone receptor expression. Conclusion: Markers of inflammation differed between primary and secondary vestibulodynia and controls.

AB - Objective: The objective of the study was to assess the association between hormone receptor densities, pain nerves, and inflammation in vestibulodynia patients. Study Design: In a prospective study, tender and nontender biopsies from 10 primary and 10 secondary vestibulodynia patients were compared with biopsies in 4 nontender controls. Hormone receptors were evaluated using immunohistochemistry for estrogen receptor-α and -β, androgen, and progesterone receptors. Inflammation, nerves, and mast cells were assessed histologically. Statistical analysis was by Fisher's exact test, analysis of variance, paired Student t test, and Wilcoxon rank test. Results: Tender sites from primary vestibulodynia had increased nerve density compared with secondary and control biopsies (P = .01). Tender sites in secondary vestibulodynia had more lymphocytes than tender primary sites and control biopsies (P <.0001). Mast cells were increased in tender sites compared with nontender and controls. There were no differences in hormone receptor expression. Conclusion: Markers of inflammation differed between primary and secondary vestibulodynia and controls.

KW - inflammation and steroid receptors

KW - primary and secondary vestibulodynia

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