Histogenesis of Malignant Melanomas of the Uvea

Occurrence of Nevus-like Structures in Experimental Choroidal Tumors

Daniel Albert, Moshe Lahav, Samuel Packer, Dean Yimoyines

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Nevus-like structures were observed at the base of experimental choroidal tumors. These neoplasms were obtained by injecting Greene transmissible hamster melanoma cells into the choroid of Syrian hamsters and murine neuroblastoma cells into the choroid of A/J strain mice. Cells from both tumors, when injected intraocularly or systemically, give rise to lesions composed predominantly of epithelioid or round cells. The choroidal tumors in both species, however, generally showed a zone of flattened cells adjacent to the sclera, composed of relatively benign-appearing, smaller, and more delicate cells—and in the case of the melanoma, usually more densely pigmented cells—than the main portion of the tumor. The cells in this area appeared similar to the “nevus cells” that have long been described beneath and adjacent to primary malignant melanomas of the uvea.

Original languageEnglish (US)
Pages (from-to)318-323
Number of pages6
JournalArchives of ophthalmology
Volume92
Issue number4
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

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Nevus
Melanoma
Neoplasms
Choroid
Sclera
Mesocricetus
Uveal melanoma
Neuroblastoma
Cricetinae

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Histogenesis of Malignant Melanomas of the Uvea : Occurrence of Nevus-like Structures in Experimental Choroidal Tumors. / Albert, Daniel; Lahav, Moshe; Packer, Samuel; Yimoyines, Dean.

In: Archives of ophthalmology, Vol. 92, No. 4, 01.01.1974, p. 318-323.

Research output: Contribution to journalArticle

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