Histochemistry of otic capsule sclerotic lesions in palmerston north autoimmune strain mice

Dennis Trune, Craig K. Hertler, Deanna K Z Haun, Ronald W. Sauter

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Otic capsule osteogenesis is a common finding in temporal bones from autoimmune disease individuals. However, the underlying cellular mechanisms are poorly understood. Therefore, to better understand this relationship of autoimmune disease and otic capsule pathology, inner ear sclerotic lesions of the Palmerston North autoimmune disease mouse were histochemically stained to identify their content and potential osteogenic processes. Lesions stained positive for calcium, amyloid, fibrinoid, and glycoproteins (PAS), but negative for collagen, calcium oxalate, reticular fibers and glycosaminoglycans (Alcian Blue). Amyloid and fibrinoid deposition are associated with other immune disease, which suggests these local processes may provide a protein substructure that calcifies in lesion progression. Similar cellular mechanisms may underlie certain types or phases of human autoimmune otic capsule disease.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalHearing Research
Volume48
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Autoimmune Diseases
Capsules
Ear
Amyloid
Reticulin
Ear Diseases
Alcian Blue
Calcium Oxalate
Temporal Bone
Bone Diseases
Immune System Diseases
Inner Ear
Glycosaminoglycans
Osteogenesis
Glycoproteins
Collagen
Pathology
Calcium
Proteins

Keywords

  • Amyloid
  • Calcium
  • Fibrinoid
  • Glycoproteins
  • Inner ear
  • Osteogenesis
  • Otic capsule

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Histochemistry of otic capsule sclerotic lesions in palmerston north autoimmune strain mice. / Trune, Dennis; Hertler, Craig K.; Haun, Deanna K Z; Sauter, Ronald W.

In: Hearing Research, Vol. 48, No. 3, 1990, p. 241-246.

Research output: Contribution to journalArticle

Trune, Dennis ; Hertler, Craig K. ; Haun, Deanna K Z ; Sauter, Ronald W. / Histochemistry of otic capsule sclerotic lesions in palmerston north autoimmune strain mice. In: Hearing Research. 1990 ; Vol. 48, No. 3. pp. 241-246.
@article{ca3aa08a35c74d84a0c931548bdab565,
title = "Histochemistry of otic capsule sclerotic lesions in palmerston north autoimmune strain mice",
abstract = "Otic capsule osteogenesis is a common finding in temporal bones from autoimmune disease individuals. However, the underlying cellular mechanisms are poorly understood. Therefore, to better understand this relationship of autoimmune disease and otic capsule pathology, inner ear sclerotic lesions of the Palmerston North autoimmune disease mouse were histochemically stained to identify their content and potential osteogenic processes. Lesions stained positive for calcium, amyloid, fibrinoid, and glycoproteins (PAS), but negative for collagen, calcium oxalate, reticular fibers and glycosaminoglycans (Alcian Blue). Amyloid and fibrinoid deposition are associated with other immune disease, which suggests these local processes may provide a protein substructure that calcifies in lesion progression. Similar cellular mechanisms may underlie certain types or phases of human autoimmune otic capsule disease.",
keywords = "Amyloid, Calcium, Fibrinoid, Glycoproteins, Inner ear, Osteogenesis, Otic capsule",
author = "Dennis Trune and Hertler, {Craig K.} and Haun, {Deanna K Z} and Sauter, {Ronald W.}",
year = "1990",
doi = "10.1016/0378-5955(90)90064-V",
language = "English (US)",
volume = "48",
pages = "241--246",
journal = "Hearing Research",
issn = "0378-5955",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Histochemistry of otic capsule sclerotic lesions in palmerston north autoimmune strain mice

AU - Trune, Dennis

AU - Hertler, Craig K.

AU - Haun, Deanna K Z

AU - Sauter, Ronald W.

PY - 1990

Y1 - 1990

N2 - Otic capsule osteogenesis is a common finding in temporal bones from autoimmune disease individuals. However, the underlying cellular mechanisms are poorly understood. Therefore, to better understand this relationship of autoimmune disease and otic capsule pathology, inner ear sclerotic lesions of the Palmerston North autoimmune disease mouse were histochemically stained to identify their content and potential osteogenic processes. Lesions stained positive for calcium, amyloid, fibrinoid, and glycoproteins (PAS), but negative for collagen, calcium oxalate, reticular fibers and glycosaminoglycans (Alcian Blue). Amyloid and fibrinoid deposition are associated with other immune disease, which suggests these local processes may provide a protein substructure that calcifies in lesion progression. Similar cellular mechanisms may underlie certain types or phases of human autoimmune otic capsule disease.

AB - Otic capsule osteogenesis is a common finding in temporal bones from autoimmune disease individuals. However, the underlying cellular mechanisms are poorly understood. Therefore, to better understand this relationship of autoimmune disease and otic capsule pathology, inner ear sclerotic lesions of the Palmerston North autoimmune disease mouse were histochemically stained to identify their content and potential osteogenic processes. Lesions stained positive for calcium, amyloid, fibrinoid, and glycoproteins (PAS), but negative for collagen, calcium oxalate, reticular fibers and glycosaminoglycans (Alcian Blue). Amyloid and fibrinoid deposition are associated with other immune disease, which suggests these local processes may provide a protein substructure that calcifies in lesion progression. Similar cellular mechanisms may underlie certain types or phases of human autoimmune otic capsule disease.

KW - Amyloid

KW - Calcium

KW - Fibrinoid

KW - Glycoproteins

KW - Inner ear

KW - Osteogenesis

KW - Otic capsule

UR - http://www.scopus.com/inward/record.url?scp=0025079721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025079721&partnerID=8YFLogxK

U2 - 10.1016/0378-5955(90)90064-V

DO - 10.1016/0378-5955(90)90064-V

M3 - Article

VL - 48

SP - 241

EP - 246

JO - Hearing Research

JF - Hearing Research

SN - 0378-5955

IS - 3

ER -