Histochemistry of otic capsule sclerotic lesions in palmerston north autoimmune strain mice

Dennis R. Trune, Craig K. Hertler, Deanna K.Z. Haun, Ronald W. Sauter

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Otic capsule osteogenesis is a common finding in temporal bones from autoimmune disease individuals. However, the underlying cellular mechanisms are poorly understood. Therefore, to better understand this relationship of autoimmune disease and otic capsule pathology, inner ear sclerotic lesions of the Palmerston North autoimmune disease mouse were histochemically stained to identify their content and potential osteogenic processes. Lesions stained positive for calcium, amyloid, fibrinoid, and glycoproteins (PAS), but negative for collagen, calcium oxalate, reticular fibers and glycosaminoglycans (Alcian Blue). Amyloid and fibrinoid deposition are associated with other immune disease, which suggests these local processes may provide a protein substructure that calcifies in lesion progression. Similar cellular mechanisms may underlie certain types or phases of human autoimmune otic capsule disease.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalHearing Research
Volume48
Issue number3
DOIs
StatePublished - Oct 1990

Keywords

  • Amyloid
  • Calcium
  • Fibrinoid
  • Glycoproteins
  • Inner ear
  • Osteogenesis
  • Otic capsule

ASJC Scopus subject areas

  • Sensory Systems

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