Histamine-2-receptor blockade does not affect hyperemia after cerebral ischemia in young swine

W. S. Tung, M. A. Helfaer, Jeffrey Kirsch, R. J. Traystman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To determine whether histamine-2 (H2) receptor antagonists can blunt the increase in cerebral blood flow after cerebral ischemia. Design: Prospective, randomized trial. Setting: Animal laboratory. Subjects: Piglets aged 1 to 2 wks. Interventions: Three groups of piglets were anesthetized with pentobarbital, mechanically ventilated, and hemodynamically monitored. Each animal was randomized to receive one of three treatments 20 mins before ischemia: famotidine (0.6 mg/kg iv), cimetidine (5 mg/kg iv), or an equivalent volume of saline (3 mL). Ischemia was maintained for 15 mins by tightening ligatures around the brachiocephalic trunk and left subclavian arteries plus the induction of hemorrhagic hypotension (50 mm Hg). Reperfusion was initiated by the reinfusion of shed blood and removal of the ligatures. Measurements and Main Results: The three groups were not different with regard to baseline arterial blood gases, cerebral perfusion pressure, microsphere-determined cerebral blood flow, or oxygen consumption (V̇O2). Ischemia (cerebral blood flow 2 values during ischemia and at 30 mins of reperfusion. Conclusions: We demonstrated that famotidine or cimetidine as compared with saline did not affect the pattern or extent of hyperemia after ischemia. This finding does not support the hypothesis that a H2-receptor mechanism is necessary for postischemic hyperemia.

Original languageEnglish (US)
Pages (from-to)260-266
Number of pages7
JournalCritical Care Medicine
Volume21
Issue number2
StatePublished - 1993
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Histamine Receptors
Hyperemia
Brain Ischemia
Swine
Ischemia
Famotidine
Cimetidine
Reperfusion
Ligation
Brachiocephalic Trunk
Subclavian Artery
Laboratory Animals
Pentobarbital
Microspheres
Oxygen Consumption
Hypotension
Gases

Keywords

  • blood flow
  • blood gas analysis
  • cerebral ischemia
  • cimetidine
  • famotidine
  • histamine
  • hyperemia
  • hypoxia
  • ischemia
  • microspheres
  • neurologic emergencies

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Histamine-2-receptor blockade does not affect hyperemia after cerebral ischemia in young swine. / Tung, W. S.; Helfaer, M. A.; Kirsch, Jeffrey; Traystman, R. J.

In: Critical Care Medicine, Vol. 21, No. 2, 1993, p. 260-266.

Research output: Contribution to journalArticle

Tung, W. S. ; Helfaer, M. A. ; Kirsch, Jeffrey ; Traystman, R. J. / Histamine-2-receptor blockade does not affect hyperemia after cerebral ischemia in young swine. In: Critical Care Medicine. 1993 ; Vol. 21, No. 2. pp. 260-266.
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