Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment

Michael Grundman, Clifford R. Jack, Ronald C. Petersen, Hyun T. Kim, Curtis Taylor, Marina Datvian, Myron F. Weiner, Charles DeCarli, Steven J. DeKosky, Christopher Van Dyck, Sultan Darvesh, Kristine Yaffe, Jeffrey Kaye, Steven H. Ferris, Ronald G. Thomas, Leon J. Thal

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Mild cognitive impairment (MCI) appears to be a transitional stage in the development of Alzheimer's disease (AD). Patients with MCI show impaired memory performance and hippocampal atrophy relative to normal elderly controls. Prior studies indicate that the degree of hippocampal atrophy in MCI patients predicts conversion to AD. In contrast to patients with MCI who have deficits primarily in memory AD patients have clinically evident impairments in both memory and nonmemory cognitive domains. One explanation for the observation that a smaller hippocampal volume predicts conversion to AD might be that hippocampal atrophy is associated with early impairment in nonmemory cognitive areas as well as memory. A link between hippocampal volume and nonmemory function could occur if hippocampal atrophy was correlated with AD pathology in other brain regions. We therefore sought to determine the relationship of hippocampal volume with performance on memory and nonmemory tasks in patients with MCI. Although we found a significant correlation between hippocampal volume and memory performance, we did not find a significant correlation between hippocampal volume and nonmemory performance. We conclude that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains.

Original languageEnglish (US)
Pages (from-to)241-248
Number of pages8
JournalJournal of Molecular Neuroscience
Volume20
Issue number3
DOIs
StatePublished - 2003
Externally publishedYes

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Alzheimer Disease
Data storage equipment
Atrophy
Pathology
Cognitive Dysfunction
Brain

Keywords

  • Alzheimer's disease
  • Alzheimer's disease assessment scale-cognitive (ADAS-Cog)
  • Hippocampus
  • Magnetic resonance imaging
  • Memory
  • Mild cognitive impairment (MCI)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry
  • Genetics

Cite this

Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment. / Grundman, Michael; Jack, Clifford R.; Petersen, Ronald C.; Kim, Hyun T.; Taylor, Curtis; Datvian, Marina; Weiner, Myron F.; DeCarli, Charles; DeKosky, Steven J.; Van Dyck, Christopher; Darvesh, Sultan; Yaffe, Kristine; Kaye, Jeffrey; Ferris, Steven H.; Thomas, Ronald G.; Thal, Leon J.

In: Journal of Molecular Neuroscience, Vol. 20, No. 3, 2003, p. 241-248.

Research output: Contribution to journalArticle

Grundman, M, Jack, CR, Petersen, RC, Kim, HT, Taylor, C, Datvian, M, Weiner, MF, DeCarli, C, DeKosky, SJ, Van Dyck, C, Darvesh, S, Yaffe, K, Kaye, J, Ferris, SH, Thomas, RG & Thal, LJ 2003, 'Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment', Journal of Molecular Neuroscience, vol. 20, no. 3, pp. 241-248. https://doi.org/10.1385/JMN:20:3:241
Grundman, Michael ; Jack, Clifford R. ; Petersen, Ronald C. ; Kim, Hyun T. ; Taylor, Curtis ; Datvian, Marina ; Weiner, Myron F. ; DeCarli, Charles ; DeKosky, Steven J. ; Van Dyck, Christopher ; Darvesh, Sultan ; Yaffe, Kristine ; Kaye, Jeffrey ; Ferris, Steven H. ; Thomas, Ronald G. ; Thal, Leon J. / Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment. In: Journal of Molecular Neuroscience. 2003 ; Vol. 20, No. 3. pp. 241-248.
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