Abstract
Mild cognitive impairment (MCI) appears to be a transitional stage in the development of Alzheimer's disease (AD). Patients with MCI show impaired memory performance and hippocampal atrophy relative to normal elderly controls. Prior studies indicate that the degree of hippocampal atrophy in MCI patients predicts conversion to AD. In contrast to patients with MCI who have deficits primarily in memory AD patients have clinically evident impairments in both memory and nonmemory cognitive domains. One explanation for the observation that a smaller hippocampal volume predicts conversion to AD might be that hippocampal atrophy is associated with early impairment in nonmemory cognitive areas as well as memory. A link between hippocampal volume and nonmemory function could occur if hippocampal atrophy was correlated with AD pathology in other brain regions. We therefore sought to determine the relationship of hippocampal volume with performance on memory and nonmemory tasks in patients with MCI. Although we found a significant correlation between hippocampal volume and memory performance, we did not find a significant correlation between hippocampal volume and nonmemory performance. We conclude that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 241-248 |
| Number of pages | 8 |
| Journal | Journal of Molecular Neuroscience |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2003 |
| Externally published | Yes |
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Keywords
- Alzheimer's disease
- Alzheimer's disease assessment scale-cognitive (ADAS-Cog)
- Hippocampus
- Magnetic resonance imaging
- Memory
- Mild cognitive impairment (MCI)
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry
- Genetics
Cite this
Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment. / Grundman, Michael; Jack, Clifford R.; Petersen, Ronald C.; Kim, Hyun T.; Taylor, Curtis; Datvian, Marina; Weiner, Myron F.; DeCarli, Charles; DeKosky, Steven J.; Van Dyck, Christopher; Darvesh, Sultan; Yaffe, Kristine; Kaye, Jeffrey; Ferris, Steven H.; Thomas, Ronald G.; Thal, Leon J.
In: Journal of Molecular Neuroscience, Vol. 20, No. 3, 2003, p. 241-248.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment
AU - Grundman, Michael
AU - Jack, Clifford R.
AU - Petersen, Ronald C.
AU - Kim, Hyun T.
AU - Taylor, Curtis
AU - Datvian, Marina
AU - Weiner, Myron F.
AU - DeCarli, Charles
AU - DeKosky, Steven J.
AU - Van Dyck, Christopher
AU - Darvesh, Sultan
AU - Yaffe, Kristine
AU - Kaye, Jeffrey
AU - Ferris, Steven H.
AU - Thomas, Ronald G.
AU - Thal, Leon J.
PY - 2003
Y1 - 2003
N2 - Mild cognitive impairment (MCI) appears to be a transitional stage in the development of Alzheimer's disease (AD). Patients with MCI show impaired memory performance and hippocampal atrophy relative to normal elderly controls. Prior studies indicate that the degree of hippocampal atrophy in MCI patients predicts conversion to AD. In contrast to patients with MCI who have deficits primarily in memory AD patients have clinically evident impairments in both memory and nonmemory cognitive domains. One explanation for the observation that a smaller hippocampal volume predicts conversion to AD might be that hippocampal atrophy is associated with early impairment in nonmemory cognitive areas as well as memory. A link between hippocampal volume and nonmemory function could occur if hippocampal atrophy was correlated with AD pathology in other brain regions. We therefore sought to determine the relationship of hippocampal volume with performance on memory and nonmemory tasks in patients with MCI. Although we found a significant correlation between hippocampal volume and memory performance, we did not find a significant correlation between hippocampal volume and nonmemory performance. We conclude that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains.
AB - Mild cognitive impairment (MCI) appears to be a transitional stage in the development of Alzheimer's disease (AD). Patients with MCI show impaired memory performance and hippocampal atrophy relative to normal elderly controls. Prior studies indicate that the degree of hippocampal atrophy in MCI patients predicts conversion to AD. In contrast to patients with MCI who have deficits primarily in memory AD patients have clinically evident impairments in both memory and nonmemory cognitive domains. One explanation for the observation that a smaller hippocampal volume predicts conversion to AD might be that hippocampal atrophy is associated with early impairment in nonmemory cognitive areas as well as memory. A link between hippocampal volume and nonmemory function could occur if hippocampal atrophy was correlated with AD pathology in other brain regions. We therefore sought to determine the relationship of hippocampal volume with performance on memory and nonmemory tasks in patients with MCI. Although we found a significant correlation between hippocampal volume and memory performance, we did not find a significant correlation between hippocampal volume and nonmemory performance. We conclude that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains.
KW - Alzheimer's disease
KW - Alzheimer's disease assessment scale-cognitive (ADAS-Cog)
KW - Hippocampus
KW - Magnetic resonance imaging
KW - Memory
KW - Mild cognitive impairment (MCI)
UR - http://www.scopus.com/inward/record.url?scp=0642310317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0642310317&partnerID=8YFLogxK
U2 - 10.1385/JMN:20:3:241
DO - 10.1385/JMN:20:3:241
M3 - Article
VL - 20
SP - 241
EP - 248
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
SN - 0895-8696
IS - 3
ER -