Hippocampal asymmetry and sudden unexpected death in infancy

A case report

Michael L. Rodriguez, Kristin McMillan, Laura A. Crandall, Megan E. Minter, Marjorie Grafe, Annapurna Poduri, Hannah C. Kinney

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The differential diagnosis of known entities associated with sudden unexpected death in infancy is ever expanding. Here we report the case of a 10-month-old infant boy whose clinical presentation mimicked that of the sudden infant death syndrome (SIDS). This presentation included the typical features of SIDS: sleep-related death; prone position upon discovery; and minor illness within 2 days of death. Nevertheless, neuropathologic examination revealed striking hippocampal asymmetry and microdysgenesis similar to that reported previously by us in toddlers with sleep-related sudden death. Hippocampal maldevelopment in the setting of sudden death in infants and toddlers is analogous to sudden unexpected death in epilepsy associated with temporal lobe pathology, and suggests a possible role for seizures in the terminal events leading to sudden death. This report serves to alert pediatric and forensic pathologists to hippocampal asymmetry and microdysgenesis in the differential diagnosis of sudden infant death mimicking SIDS.

Original languageEnglish (US)
Pages (from-to)441-446
Number of pages6
JournalForensic Science, Medicine, and Pathology
Volume8
Issue number4
DOIs
StatePublished - 2012

Fingerprint

Sudden Infant Death
Sudden Death
Sleep
Differential Diagnosis
Prone Position
Temporal Lobe
Epilepsy
Seizures
Pediatrics
Pathology

Keywords

  • Apnea
  • Febrile seizures
  • Microdysgenesis
  • Sudden infant death syndrome (SIDS)
  • Sudden unexpected death in epilepsy (SUDEP)
  • Temporal lobe

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Rodriguez, M. L., McMillan, K., Crandall, L. A., Minter, M. E., Grafe, M., Poduri, A., & Kinney, H. C. (2012). Hippocampal asymmetry and sudden unexpected death in infancy: A case report. Forensic Science, Medicine, and Pathology, 8(4), 441-446. https://doi.org/10.1007/s12024-012-9367-5

Hippocampal asymmetry and sudden unexpected death in infancy : A case report. / Rodriguez, Michael L.; McMillan, Kristin; Crandall, Laura A.; Minter, Megan E.; Grafe, Marjorie; Poduri, Annapurna; Kinney, Hannah C.

In: Forensic Science, Medicine, and Pathology, Vol. 8, No. 4, 2012, p. 441-446.

Research output: Contribution to journalArticle

Rodriguez, ML, McMillan, K, Crandall, LA, Minter, ME, Grafe, M, Poduri, A & Kinney, HC 2012, 'Hippocampal asymmetry and sudden unexpected death in infancy: A case report', Forensic Science, Medicine, and Pathology, vol. 8, no. 4, pp. 441-446. https://doi.org/10.1007/s12024-012-9367-5
Rodriguez, Michael L. ; McMillan, Kristin ; Crandall, Laura A. ; Minter, Megan E. ; Grafe, Marjorie ; Poduri, Annapurna ; Kinney, Hannah C. / Hippocampal asymmetry and sudden unexpected death in infancy : A case report. In: Forensic Science, Medicine, and Pathology. 2012 ; Vol. 8, No. 4. pp. 441-446.
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