Highly efficient one step synthesis of primary amines from B-Chlorodialkylboranes

Sanjay V. Malhotra; Herbert C. Brown

doi:10.2174/157017812801322453

Highly efficient one step synthesis of primary amines from B-Chlorodialkylboranes

Research output: Contribution to journal › Article › peer-review

Abstract

A convenient and simple method for synthesis of primary amines has been developed by direct amination of B-Chlorodialkylboranes. This general procedure has been applied to synthesize acyclic, cyclic, hindered and chiral amines in very high yields using both hydroxylamine-O-sulfonic acid and monochloroamine as reagents.

Original language	English (US)
Pages (from-to)	383-385
Number of pages	3
Journal	Letters in Organic Chemistry
Volume	9
Issue number	6
DOIs	https://doi.org/10.2174/157017812801322453
State	Published - Jul 2012
Externally published	Yes

Keywords

Amination
B-Chlorodialkylboranes
Chiral amine
Organoborane

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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abstract = "A convenient and simple method for synthesis of primary amines has been developed by direct amination of B-Chlorodialkylboranes. This general procedure has been applied to synthesize acyclic, cyclic, hindered and chiral amines in very high yields using both hydroxylamine-O-sulfonic acid and monochloroamine as reagents.",

keywords = "Amination, B-Chlorodialkylboranes, Chiral amine, Organoborane",

author = "Malhotra, {Sanjay V.} and Brown, {Herbert C.}",

year = "2012",

month = jul,

doi = "10.2174/157017812801322453",

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issn = "1570-1786",

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AU - Malhotra, Sanjay V.

AU - Brown, Herbert C.

PY - 2012/7

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N2 - A convenient and simple method for synthesis of primary amines has been developed by direct amination of B-Chlorodialkylboranes. This general procedure has been applied to synthesize acyclic, cyclic, hindered and chiral amines in very high yields using both hydroxylamine-O-sulfonic acid and monochloroamine as reagents.

AB - A convenient and simple method for synthesis of primary amines has been developed by direct amination of B-Chlorodialkylboranes. This general procedure has been applied to synthesize acyclic, cyclic, hindered and chiral amines in very high yields using both hydroxylamine-O-sulfonic acid and monochloroamine as reagents.

KW - Amination

KW - B-Chlorodialkylboranes

KW - Chiral amine

KW - Organoborane

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ER -

Highly efficient one step synthesis of primary amines from B-Chlorodialkylboranes

Abstract

Keywords

ASJC Scopus subject areas

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