Highly efficient method for C-5 halogenation of pyrimidine-based nucleosides in ionic liquids

Vineet Kumar, Jeremy Yap, Andrew Muroyama, Sanjay V. Malhotra

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A novel, highly efficient, convenient, and benign methodology for C-5 halogenation of pyrimidine-based nucleosides has been developed using N-halosuccinimides as halogenating reagents without using any catalyst in ionic liquid medium. The ionic liquids were successfully recovered and reused for all the reactions.

Original languageEnglish (US)
Article numberM01709SS
Pages (from-to)3957-3962
Number of pages6
JournalSynthesis
Issue number23
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Halogenation
  • Ionic liquids
  • Nucleosides

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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