Highly-efficient and versatile fluorous-tagged Cu(i)-catalyzed azide-alkyne cycloaddition ligand for preparing bioconjugates

Lingyi Sun, Yongkang Gai, Carolyn J. Anderson, Dexing Zeng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A novel ligand (FBTTBE) for Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) has been developed, which demonstrates not only superior catalytic efficiency but also the ease of removing toxic copper species. FBTTBE has also been successfully applied in the synthesis of radiometal-labeled peptide and antibody without observable transchelation with the non-radioactive Cu(i) catalyst.

Original languageEnglish (US)
Pages (from-to)17072-17075
Number of pages4
JournalChemical Communications
Volume51
Issue number96
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Alkynes
Azides
Cycloaddition
Poisons
Antibodies
Peptides
Copper
Ligands
Catalysts

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Highly-efficient and versatile fluorous-tagged Cu(i)-catalyzed azide-alkyne cycloaddition ligand for preparing bioconjugates. / Sun, Lingyi; Gai, Yongkang; Anderson, Carolyn J.; Zeng, Dexing.

In: Chemical Communications, Vol. 51, No. 96, 01.01.2015, p. 17072-17075.

Research output: Contribution to journalArticle

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