Abstract
The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Here we review three papers to highlight the role of the adenosine 1 receptor (A1AR) as a potential mediator and physiological regulator of a hypothermic state in both hibernating and non-hibernating mammals. We would like to emphasize the importance of comparative studies between hibernating and non-hibernating species that could lead to important discoveries on the mechanisms inducing hibernation and how they might be translated to induce a clinically useful hypothermic state.
Original language | English (US) |
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Pages (from-to) | 1-2 |
Number of pages | 2 |
Journal | Autonomic Neuroscience: Basic and Clinical |
Volume | 176 |
Issue number | 1-2 |
DOIs | |
State | Published - Jun 2013 |
Keywords
- Adenosine
- Hypothermia
- Ischemic injury
- Thermoregulation
- Torpor
ASJC Scopus subject areas
- Endocrine and Autonomic Systems
- Clinical Neurology
- Cellular and Molecular Neuroscience