Highlights in basic autonomic neurosciences: Central adenosine A1 receptor - The key to a hypometabolic state and therapeutic hypothermia?

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Here we review three papers to highlight the role of the adenosine 1 receptor (A1AR) as a potential mediator and physiological regulator of a hypothermic state in both hibernating and non-hibernating mammals. We would like to emphasize the importance of comparative studies between hibernating and non-hibernating species that could lead to important discoveries on the mechanisms inducing hibernation and how they might be translated to induce a clinically useful hypothermic state.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalAutonomic Neuroscience: Basic and Clinical
Volume176
Issue number1-2
DOIs
StatePublished - Jun 1 2013

Keywords

  • Adenosine
  • Hypothermia
  • Ischemic injury
  • Thermoregulation
  • Torpor

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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