@article{fb283f1aa2094f3b83754203ec08fb57,
title = "Highlights from the Tenth International Workshop on HIV Persistence during Therapy, December 13-16, 2022, Miami, Florida-USA",
abstract = "The International Workshop on HIV Persistence during Therapy provides a forum in which HIV/AIDS researchers gather to share the latest research findings related to viral reservoirs and cure. The Tenth Workshop, which was attended by over 400 delegates, extended over 4 days and comprised eight sessions covering topics from the basic science of viral persistence to therapeutic approaches to HIV cure. Furthermore, satellite sessions on the first day of the Conference featuring cure research endeavours being pursued by the Bill and Melinda Gates Foundation as well as those being coordinated under the National Institutes of Health Martin Delaney Collaboratory program, provided important updates on research advances being made in these initiatives. As with previous conferences, the International Workshop on HIV Persistence during Therapy is primarily abstract-driven with only one invited talk for each of the sessions. This format, therefore, increases the number of presentations from early-stage investigators. Furthermore, presentations by Community representatives illustrated approaches to creating cure research literacy with effective messaging for the Community. The following article offers a synopsis of the meeting sessions. Due to space constraints, some presentations may have only been briefly discussed. Nevertheless, the Workshop abstracts can be found online (https://www/sciencedirect.com/journal/journal-of-virus-eradication/vol/8/suppl/S).",
keywords = "HIV cure, HIV eradication, HIV functional Cure, HIV persistence, HIV reservoirs",
author = "N. Archin and Bar, {K. J.} and T. Burdo and M. Caskey and A. Chahroudi and M. Farzan and Ho, {Y. C.} and Jones, {R. B.} and Mary Kearney and D. Kuritzkes and D. Margolis and J. Martinez-Picado and A. Okoye and M. Salgado and Mario Stevenson",
note = "Funding Information: Focusing on a second compartment of HIV persistence, M, Wang and al. (Yale University, USA) explored the types of HIV-infected CD4+ T cells in cerebral spinal fluid (CSF) and how they related to the peripheral blood. Using single-cell analyses, they found that HIV RNA expressing cells in the CSF were predominantly expanded clones of central memory CD4+ T cells. Sequencing revealed increased expansion of T cell clones in the CSF compared to blood, with lower overlap between CSF and peripheral clones in some participants. Together, these results support the compartmentalization of some HIV-infected T cells within the CNS and highlight the need to continue study of this potentially distinct HIV reservoir.In summary, this session on the Immunology of Persistence raised new insights in several areas of relevance to the field. Beginning with HIV persistence in lymph node follicles, authors addressed the evolving role of cytotoxic T cells in HIV containment and the potential for immunotherapy to drive more effective NK responses. In vitro studies supported a pro-latency role for CD8+ T cells in HIV persistence, while HIV persistence in the CNS was shown to involve clonal expansion of potentially CNS-specific HIV-infected CD4+ T cells. Several studies sought cellular immune correlates of ongoing HIV expression and declining intact virus reservoirs over time, elucidating the complex, likely multidirectional relationship between persistent HIV antigen production and HIV-specific CD8+ T cell numbers and function, and identified galectin-9 as a potential marker of HIV decay. Together, these presentations highlighted key areas of current and future study. Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = mar,
doi = "10.1016/j.jve.2023.100315",
language = "English (US)",
volume = "9",
journal = "Journal of Virus Eradication",
issn = "2055-6640",
publisher = "Mediscript Ltd",
number = "1",
}