Higher sensitivity of CA1 synapses to aglycemia in streptozotocin- diabetic rats is age-dependent

Selva Tekkök, Jasna Križ, Ante L. Padjen, Krešimir Krnjević

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We studied conduction velocity in peripheral nerves and the block of synaptic transmission produced by lack of glucose in hippocampal slices from 4- and 12-month-old streptozotocin-induced diabetic rats and their age- matched controls. In sural nerves of young and old diabetic rats, the conduction velocity was reduced by 30-35%. In slices from young diabetics, CA1 synaptic transmission was more sensitive to aglycemia than in control slices. However, all slices from older rats showed comparable increases in CA1 synaptic sensitivity to aglycemia. We conclude that the cerebral adaptation to diabetic hyperglycemia apparent in the hippocampus of young rats is masked in older rats by an age-dependent increase in sensitivity to lack of glucose.

Original languageEnglish (US)
Pages (from-to)268-273
Number of pages6
JournalBrain research
Volume813
Issue number2
DOIs
StatePublished - Dec 7 1998
Externally publishedYes

Keywords

  • Adenosine
  • Conduction velocity
  • Peripheral nerves
  • Rheobase and chronaxie
  • Young and old

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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