Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results

Michael A. Pulsipher, Brent R. Logan, Deidre M. Kiefer, Pintip Chitphakdithai, Marcie L. Riches, J. Douglas Rizzo, Paolo Anderlini, Susan F. Leitman, James W. Varni, Hati Kobusingye, Rae Anne M. Besser, John P. Miller, Rebecca J. Drexler, Aly Abdel-Mageed, Ibrahim A. Ahmed, Edward D. Ball, Brian J. Bolwell, Nancy J. Bunin, Alexandra Cheerva, David C. DelgadoChristopher C. Dvorak, Alfred P. Gillio, Theresa E. Hahn, Gregory A. Hale, Ann E. Haight, Brandon Hayes-Lattin, Kimberly A. Kasow, Michael Linenberger, Margarida Magalhaes-Silverman, Shahram Mori, Vinod K. Prasad, Troy C. Quigg, Indira Sahdev, Jeffrey R. Schriber, Shalini Shenoy, William T. Tse, Gregory A. Yanik, Willis H. Navarro, Mary M. Horowitz, Dennis L. Confer, Bronwen E. Shaw, Galen E. Switzer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although donation of bone marrow (BM)or peripheral blood stem cells (PBSCs)from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. To address this lack, we prospectively enrolled 294 donors age <18 years at 25 pediatric transplantation centers in North America, assessing them predonation, peridonation, and at 1 month, 6 months, and 1 year postdonation. We noted that 71% of children reported pain and 59% reported other symptoms peridonation, with resolution to 14% and 12% at 1 month postdonation. Both older age (age 13 to 17 years versus younger)and female sex were associated with higher levels of pain peridonation, with the highest rates in older females (57% with grade 2-4 pain and 17% with grade 3-4 pain). Multivariate analyses showed a 4-fold increase in risk for older females compared with males age <13 years (P <.001). At 1 year, 11% of 13- to 17-year-old females reported grade 2-4 pain, compared with 3% of males age 13 to 17 years, 0% of females age <13 years, and 1% of males age <13 years (P =.01). Males and females age 13 to 17 years failed to return to predonation pain levels at 1 year 22% and 23% of the time, respectively, compared with 3% and 10% in males and females age <13 years (P =.002). Our data show that females age 13 to 17 years are at increased risk of grade 2-4 pain at 1 year and >20% of females and males age 13 to 17 years do not return to baseline pain levels by 1 year after BM donation. Studies aimed at decreasing symptoms and improving recovery in older children are warranted.

Original languageEnglish (US)
Pages (from-to)955-964
Number of pages10
JournalBiology of Blood and Marrow Transplantation
Volume25
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Bone Marrow
Pain
Homologous Transplantation
Tissue Donors
Peripheral Blood Stem Cells

Keywords

  • BM collection toxicities
  • Donor safety
  • PBSC collection toxicities
  • Stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Pulsipher, M. A., Logan, B. R., Kiefer, D. M., Chitphakdithai, P., Riches, M. L., Rizzo, J. D., ... Switzer, G. E. (2019). Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results. Biology of Blood and Marrow Transplantation, 25(5), 955-964. https://doi.org/10.1016/j.bbmt.2018.12.765

Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation : RDSafe Peds Results. / Pulsipher, Michael A.; Logan, Brent R.; Kiefer, Deidre M.; Chitphakdithai, Pintip; Riches, Marcie L.; Rizzo, J. Douglas; Anderlini, Paolo; Leitman, Susan F.; Varni, James W.; Kobusingye, Hati; Besser, Rae Anne M.; Miller, John P.; Drexler, Rebecca J.; Abdel-Mageed, Aly; Ahmed, Ibrahim A.; Ball, Edward D.; Bolwell, Brian J.; Bunin, Nancy J.; Cheerva, Alexandra; Delgado, David C.; Dvorak, Christopher C.; Gillio, Alfred P.; Hahn, Theresa E.; Hale, Gregory A.; Haight, Ann E.; Hayes-Lattin, Brandon; Kasow, Kimberly A.; Linenberger, Michael; Magalhaes-Silverman, Margarida; Mori, Shahram; Prasad, Vinod K.; Quigg, Troy C.; Sahdev, Indira; Schriber, Jeffrey R.; Shenoy, Shalini; Tse, William T.; Yanik, Gregory A.; Navarro, Willis H.; Horowitz, Mary M.; Confer, Dennis L.; Shaw, Bronwen E.; Switzer, Galen E.

In: Biology of Blood and Marrow Transplantation, Vol. 25, No. 5, 01.05.2019, p. 955-964.

Research output: Contribution to journalArticle

Pulsipher, MA, Logan, BR, Kiefer, DM, Chitphakdithai, P, Riches, ML, Rizzo, JD, Anderlini, P, Leitman, SF, Varni, JW, Kobusingye, H, Besser, RAM, Miller, JP, Drexler, RJ, Abdel-Mageed, A, Ahmed, IA, Ball, ED, Bolwell, BJ, Bunin, NJ, Cheerva, A, Delgado, DC, Dvorak, CC, Gillio, AP, Hahn, TE, Hale, GA, Haight, AE, Hayes-Lattin, B, Kasow, KA, Linenberger, M, Magalhaes-Silverman, M, Mori, S, Prasad, VK, Quigg, TC, Sahdev, I, Schriber, JR, Shenoy, S, Tse, WT, Yanik, GA, Navarro, WH, Horowitz, MM, Confer, DL, Shaw, BE & Switzer, GE 2019, 'Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results', Biology of Blood and Marrow Transplantation, vol. 25, no. 5, pp. 955-964. https://doi.org/10.1016/j.bbmt.2018.12.765
Pulsipher, Michael A. ; Logan, Brent R. ; Kiefer, Deidre M. ; Chitphakdithai, Pintip ; Riches, Marcie L. ; Rizzo, J. Douglas ; Anderlini, Paolo ; Leitman, Susan F. ; Varni, James W. ; Kobusingye, Hati ; Besser, Rae Anne M. ; Miller, John P. ; Drexler, Rebecca J. ; Abdel-Mageed, Aly ; Ahmed, Ibrahim A. ; Ball, Edward D. ; Bolwell, Brian J. ; Bunin, Nancy J. ; Cheerva, Alexandra ; Delgado, David C. ; Dvorak, Christopher C. ; Gillio, Alfred P. ; Hahn, Theresa E. ; Hale, Gregory A. ; Haight, Ann E. ; Hayes-Lattin, Brandon ; Kasow, Kimberly A. ; Linenberger, Michael ; Magalhaes-Silverman, Margarida ; Mori, Shahram ; Prasad, Vinod K. ; Quigg, Troy C. ; Sahdev, Indira ; Schriber, Jeffrey R. ; Shenoy, Shalini ; Tse, William T. ; Yanik, Gregory A. ; Navarro, Willis H. ; Horowitz, Mary M. ; Confer, Dennis L. ; Shaw, Bronwen E. ; Switzer, Galen E. / Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation : RDSafe Peds Results. In: Biology of Blood and Marrow Transplantation. 2019 ; Vol. 25, No. 5. pp. 955-964.
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abstract = "Although donation of bone marrow (BM)or peripheral blood stem cells (PBSCs)from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. To address this lack, we prospectively enrolled 294 donors age <18 years at 25 pediatric transplantation centers in North America, assessing them predonation, peridonation, and at 1 month, 6 months, and 1 year postdonation. We noted that 71{\%} of children reported pain and 59{\%} reported other symptoms peridonation, with resolution to 14{\%} and 12{\%} at 1 month postdonation. Both older age (age 13 to 17 years versus younger)and female sex were associated with higher levels of pain peridonation, with the highest rates in older females (57{\%} with grade 2-4 pain and 17{\%} with grade 3-4 pain). Multivariate analyses showed a 4-fold increase in risk for older females compared with males age <13 years (P <.001). At 1 year, 11{\%} of 13- to 17-year-old females reported grade 2-4 pain, compared with 3{\%} of males age 13 to 17 years, 0{\%} of females age <13 years, and 1{\%} of males age <13 years (P =.01). Males and females age 13 to 17 years failed to return to predonation pain levels at 1 year 22{\%} and 23{\%} of the time, respectively, compared with 3{\%} and 10{\%} in males and females age <13 years (P =.002). Our data show that females age 13 to 17 years are at increased risk of grade 2-4 pain at 1 year and >20{\%} of females and males age 13 to 17 years do not return to baseline pain levels by 1 year after BM donation. Studies aimed at decreasing symptoms and improving recovery in older children are warranted.",
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T1 - Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation

T2 - RDSafe Peds Results

AU - Pulsipher, Michael A.

AU - Logan, Brent R.

AU - Kiefer, Deidre M.

AU - Chitphakdithai, Pintip

AU - Riches, Marcie L.

AU - Rizzo, J. Douglas

AU - Anderlini, Paolo

AU - Leitman, Susan F.

AU - Varni, James W.

AU - Kobusingye, Hati

AU - Besser, Rae Anne M.

AU - Miller, John P.

AU - Drexler, Rebecca J.

AU - Abdel-Mageed, Aly

AU - Ahmed, Ibrahim A.

AU - Ball, Edward D.

AU - Bolwell, Brian J.

AU - Bunin, Nancy J.

AU - Cheerva, Alexandra

AU - Delgado, David C.

AU - Dvorak, Christopher C.

AU - Gillio, Alfred P.

AU - Hahn, Theresa E.

AU - Hale, Gregory A.

AU - Haight, Ann E.

AU - Hayes-Lattin, Brandon

AU - Kasow, Kimberly A.

AU - Linenberger, Michael

AU - Magalhaes-Silverman, Margarida

AU - Mori, Shahram

AU - Prasad, Vinod K.

AU - Quigg, Troy C.

AU - Sahdev, Indira

AU - Schriber, Jeffrey R.

AU - Shenoy, Shalini

AU - Tse, William T.

AU - Yanik, Gregory A.

AU - Navarro, Willis H.

AU - Horowitz, Mary M.

AU - Confer, Dennis L.

AU - Shaw, Bronwen E.

AU - Switzer, Galen E.

PY - 2019/5/1

Y1 - 2019/5/1

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AB - Although donation of bone marrow (BM)or peripheral blood stem cells (PBSCs)from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. To address this lack, we prospectively enrolled 294 donors age <18 years at 25 pediatric transplantation centers in North America, assessing them predonation, peridonation, and at 1 month, 6 months, and 1 year postdonation. We noted that 71% of children reported pain and 59% reported other symptoms peridonation, with resolution to 14% and 12% at 1 month postdonation. Both older age (age 13 to 17 years versus younger)and female sex were associated with higher levels of pain peridonation, with the highest rates in older females (57% with grade 2-4 pain and 17% with grade 3-4 pain). Multivariate analyses showed a 4-fold increase in risk for older females compared with males age <13 years (P <.001). At 1 year, 11% of 13- to 17-year-old females reported grade 2-4 pain, compared with 3% of males age 13 to 17 years, 0% of females age <13 years, and 1% of males age <13 years (P =.01). Males and females age 13 to 17 years failed to return to predonation pain levels at 1 year 22% and 23% of the time, respectively, compared with 3% and 10% in males and females age <13 years (P =.002). Our data show that females age 13 to 17 years are at increased risk of grade 2-4 pain at 1 year and >20% of females and males age 13 to 17 years do not return to baseline pain levels by 1 year after BM donation. Studies aimed at decreasing symptoms and improving recovery in older children are warranted.

KW - BM collection toxicities

KW - Donor safety

KW - PBSC collection toxicities

KW - Stem cell transplantation

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