Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030)

S. G. Louie, B. Ely, H. J. Lenz, K. S. Albain, C. Gotay, D. Coleman, D. Raghavan, A. F. Shields, P. J. Gold, Charles Blanke

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background:The aging process is accompanied by physiological changes including reduced glomerular filtration and hepatic function, as well as changes in gastric secretions. To investigate what effect would aging have on the disposition of capecitabine and its metabolites, the pharmacokinetics between patients ≥70 years and 60 years.

Original languageEnglish (US)
Pages (from-to)1744-1749
Number of pages6
JournalBritish Journal of Cancer
Volume109
Issue number7
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

Fingerprint

Area Under Curve
Colorectal Neoplasms
Stomach
Pharmacokinetics
Liver
Capecitabine

Keywords

  • capecitabine
  • colorectal cancer
  • elderly
  • pharmacokinetics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030). / Louie, S. G.; Ely, B.; Lenz, H. J.; Albain, K. S.; Gotay, C.; Coleman, D.; Raghavan, D.; Shields, A. F.; Gold, P. J.; Blanke, Charles.

In: British Journal of Cancer, Vol. 109, No. 7, 01.10.2013, p. 1744-1749.

Research output: Contribution to journalArticle

Louie, SG, Ely, B, Lenz, HJ, Albain, KS, Gotay, C, Coleman, D, Raghavan, D, Shields, AF, Gold, PJ & Blanke, C 2013, 'Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030)', British Journal of Cancer, vol. 109, no. 7, pp. 1744-1749. https://doi.org/10.1038/bjc.2013.517
Louie, S. G. ; Ely, B. ; Lenz, H. J. ; Albain, K. S. ; Gotay, C. ; Coleman, D. ; Raghavan, D. ; Shields, A. F. ; Gold, P. J. ; Blanke, Charles. / Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030). In: British Journal of Cancer. 2013 ; Vol. 109, No. 7. pp. 1744-1749.
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AU - Blanke, Charles

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