Higher baseline CD4 cell count predicts treatment interruptions and persistent viremia in patients initiating ARVs in rural uganda

Susan A. Adakun, Mark J. Siedner, Conrad Muzoora, Jessica E. Haberer, Alexander C. Tsai, Peter W. Hunt, Jeff N. Martin, David Bangsberg

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We examined the association between CD4 cell count and adherence in a cohort of Ugandans initiating antiretrovirals (ARVs). Outcomes were (a) adherence < 90%; (b) any treatment interruptions . 72 hours; (c) number of treatment interruptions; and (d) HIV-RNA > 400 copies/μL. We fit regression models to estimate associations with our exposure of interest, baseline CD4 cell count ≥ 250 cells/μL (n = 60) vs > 250 cells/μL (n = 413). CD4 cell count ≥250 cells/μL was independently associated with increased odds and number of treatment interruptions and increased odds of persistent viremia. Interventions to support adherence in patients with higher CD4 cell counts should be considered as drug availability to this population increases.

Original languageEnglish (US)
Pages (from-to)317-321
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume62
Issue number3
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

Fingerprint

Uganda
Viremia
CD4 Lymphocyte Count
Therapeutics
Patient Compliance
Pharmaceutical Preparations
Population

Keywords

  • Adherence
  • Adherence monitoring
  • HIV/aids
  • MEMS
  • Test and treat
  • Uganda

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Higher baseline CD4 cell count predicts treatment interruptions and persistent viremia in patients initiating ARVs in rural uganda. / Adakun, Susan A.; Siedner, Mark J.; Muzoora, Conrad; Haberer, Jessica E.; Tsai, Alexander C.; Hunt, Peter W.; Martin, Jeff N.; Bangsberg, David.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 62, No. 3, 01.03.2013, p. 317-321.

Research output: Contribution to journalArticle

Adakun, Susan A. ; Siedner, Mark J. ; Muzoora, Conrad ; Haberer, Jessica E. ; Tsai, Alexander C. ; Hunt, Peter W. ; Martin, Jeff N. ; Bangsberg, David. / Higher baseline CD4 cell count predicts treatment interruptions and persistent viremia in patients initiating ARVs in rural uganda. In: Journal of Acquired Immune Deficiency Syndromes. 2013 ; Vol. 62, No. 3. pp. 317-321.
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