High-speed Optical Coherence Tomography of Corneal Opacities

Rahul N. Khurana, Yan Li, Maolong Tang, Michael M. Lai, David Huang

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Purpose: To evaluate corneal opacities with optical coherence tomography (OCT). Design: Prospective observational case series. Participants: Twenty-three eyes of 19 patients with corneal opacities referred to a tertiary medical center. Methods: Twenty-three consecutive eyes with corneal opacities were imaged with a high-speed corneal OCT prototype (Carl Zeiss Meditec, Inc., Dublin, CA). The OCT system operates at a speed of 2000 axial scans per second and a wavelength of 1.3 μm. Slit-scanning tomography (Orbscan II, software version 3.12; Bausch & Lomb, Inc., Rochester, NY) and ultrasound pachymetry (Corneo-Gage Plus; Sonogage, Cleveland, OH) also were performed. Main Outcome Measures: Central cornea thickness was measured by the 3 instruments. Results: In eyes with central opacities (n = 17), OCT central cornea thickness measurements were statistically equivalent to ultrasound pachymetry, whereas Orbscan II measurements were significantly less than ultrasound pachymetry (difference, -132.7±143 μm; P = 0.006). The OCT and ultrasound pachymetry results were obtained for all eyes, whereas Orbscan was unable to provide readings in 4 eyes. In eyes with off-center opacities (n = 6), OCT and Orbscan II central cornea thickness measurements were statistically equivalent to ultrasound pachymetry. The OCT measurements of epithelial thickness and scar depth also were demonstrated. Conclusions: Optical coherence tomography provides consistent pachymetry mapping, whereas Orbscan II significantly underestimates corneal thickness in the presence of central corneal scars. Optical coherence tomography could be valuable in the planning of surgical treatment of corneal scars.

Original languageEnglish (US)
Pages (from-to)1278-1285
Number of pages8
JournalOphthalmology
Volume114
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

Corneal Opacity
Optical Coherence Tomography
Cornea
Cicatrix
Reading
Software
Tomography
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

High-speed Optical Coherence Tomography of Corneal Opacities. / Khurana, Rahul N.; Li, Yan; Tang, Maolong; Lai, Michael M.; Huang, David.

In: Ophthalmology, Vol. 114, No. 7, 07.2007, p. 1278-1285.

Research output: Contribution to journalArticle

Khurana, Rahul N. ; Li, Yan ; Tang, Maolong ; Lai, Michael M. ; Huang, David. / High-speed Optical Coherence Tomography of Corneal Opacities. In: Ophthalmology. 2007 ; Vol. 114, No. 7. pp. 1278-1285.
@article{a3188c6c95c3407eb8a3300d0f759c61,
title = "High-speed Optical Coherence Tomography of Corneal Opacities",
abstract = "Purpose: To evaluate corneal opacities with optical coherence tomography (OCT). Design: Prospective observational case series. Participants: Twenty-three eyes of 19 patients with corneal opacities referred to a tertiary medical center. Methods: Twenty-three consecutive eyes with corneal opacities were imaged with a high-speed corneal OCT prototype (Carl Zeiss Meditec, Inc., Dublin, CA). The OCT system operates at a speed of 2000 axial scans per second and a wavelength of 1.3 μm. Slit-scanning tomography (Orbscan II, software version 3.12; Bausch & Lomb, Inc., Rochester, NY) and ultrasound pachymetry (Corneo-Gage Plus; Sonogage, Cleveland, OH) also were performed. Main Outcome Measures: Central cornea thickness was measured by the 3 instruments. Results: In eyes with central opacities (n = 17), OCT central cornea thickness measurements were statistically equivalent to ultrasound pachymetry, whereas Orbscan II measurements were significantly less than ultrasound pachymetry (difference, -132.7±143 μm; P = 0.006). The OCT and ultrasound pachymetry results were obtained for all eyes, whereas Orbscan was unable to provide readings in 4 eyes. In eyes with off-center opacities (n = 6), OCT and Orbscan II central cornea thickness measurements were statistically equivalent to ultrasound pachymetry. The OCT measurements of epithelial thickness and scar depth also were demonstrated. Conclusions: Optical coherence tomography provides consistent pachymetry mapping, whereas Orbscan II significantly underestimates corneal thickness in the presence of central corneal scars. Optical coherence tomography could be valuable in the planning of surgical treatment of corneal scars.",
author = "Khurana, {Rahul N.} and Yan Li and Maolong Tang and Lai, {Michael M.} and David Huang",
year = "2007",
month = "7",
doi = "10.1016/j.ophtha.2006.10.033",
language = "English (US)",
volume = "114",
pages = "1278--1285",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - High-speed Optical Coherence Tomography of Corneal Opacities

AU - Khurana, Rahul N.

AU - Li, Yan

AU - Tang, Maolong

AU - Lai, Michael M.

AU - Huang, David

PY - 2007/7

Y1 - 2007/7

N2 - Purpose: To evaluate corneal opacities with optical coherence tomography (OCT). Design: Prospective observational case series. Participants: Twenty-three eyes of 19 patients with corneal opacities referred to a tertiary medical center. Methods: Twenty-three consecutive eyes with corneal opacities were imaged with a high-speed corneal OCT prototype (Carl Zeiss Meditec, Inc., Dublin, CA). The OCT system operates at a speed of 2000 axial scans per second and a wavelength of 1.3 μm. Slit-scanning tomography (Orbscan II, software version 3.12; Bausch & Lomb, Inc., Rochester, NY) and ultrasound pachymetry (Corneo-Gage Plus; Sonogage, Cleveland, OH) also were performed. Main Outcome Measures: Central cornea thickness was measured by the 3 instruments. Results: In eyes with central opacities (n = 17), OCT central cornea thickness measurements were statistically equivalent to ultrasound pachymetry, whereas Orbscan II measurements were significantly less than ultrasound pachymetry (difference, -132.7±143 μm; P = 0.006). The OCT and ultrasound pachymetry results were obtained for all eyes, whereas Orbscan was unable to provide readings in 4 eyes. In eyes with off-center opacities (n = 6), OCT and Orbscan II central cornea thickness measurements were statistically equivalent to ultrasound pachymetry. The OCT measurements of epithelial thickness and scar depth also were demonstrated. Conclusions: Optical coherence tomography provides consistent pachymetry mapping, whereas Orbscan II significantly underestimates corneal thickness in the presence of central corneal scars. Optical coherence tomography could be valuable in the planning of surgical treatment of corneal scars.

AB - Purpose: To evaluate corneal opacities with optical coherence tomography (OCT). Design: Prospective observational case series. Participants: Twenty-three eyes of 19 patients with corneal opacities referred to a tertiary medical center. Methods: Twenty-three consecutive eyes with corneal opacities were imaged with a high-speed corneal OCT prototype (Carl Zeiss Meditec, Inc., Dublin, CA). The OCT system operates at a speed of 2000 axial scans per second and a wavelength of 1.3 μm. Slit-scanning tomography (Orbscan II, software version 3.12; Bausch & Lomb, Inc., Rochester, NY) and ultrasound pachymetry (Corneo-Gage Plus; Sonogage, Cleveland, OH) also were performed. Main Outcome Measures: Central cornea thickness was measured by the 3 instruments. Results: In eyes with central opacities (n = 17), OCT central cornea thickness measurements were statistically equivalent to ultrasound pachymetry, whereas Orbscan II measurements were significantly less than ultrasound pachymetry (difference, -132.7±143 μm; P = 0.006). The OCT and ultrasound pachymetry results were obtained for all eyes, whereas Orbscan was unable to provide readings in 4 eyes. In eyes with off-center opacities (n = 6), OCT and Orbscan II central cornea thickness measurements were statistically equivalent to ultrasound pachymetry. The OCT measurements of epithelial thickness and scar depth also were demonstrated. Conclusions: Optical coherence tomography provides consistent pachymetry mapping, whereas Orbscan II significantly underestimates corneal thickness in the presence of central corneal scars. Optical coherence tomography could be valuable in the planning of surgical treatment of corneal scars.

UR - http://www.scopus.com/inward/record.url?scp=34347228171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347228171&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2006.10.033

DO - 10.1016/j.ophtha.2006.10.033

M3 - Article

C2 - 17307254

AN - SCOPUS:34347228171

VL - 114

SP - 1278

EP - 1285

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 7

ER -