High serum testosterone is associated with reduced risk of cardiovascular events in elderly men: The MrOS (osteoporotic fractures in men) study in Sweden

Claes Ohlsson, Elizabeth Barrett-Connor, Shalender Bhasin, Eric Orwoll, Fernand Labrie, Magnus K. Karlsson, Östen Ljunggren, Liesbeth Vandenput, Dan Mellström, Åsa Tivesten

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Objectives: We tested the hypothesis that serum total testosterone and sex hormonebinding globulin (SHBG) levels predict cardiovascular (CV) events in community-dwelling elderly men. Background: Low serum testosterone is associated with increased adiposity, an adverse metabolic risk profile, and atherosclerosis. However, few prospective studies have demonstrated a protective link between endogenous testosterone and CV events. Polymorphisms in the SHBG gene are associated with risk of type 2 diabetes, but few studies have addressed SHBG as a predictor of CV events. Methods: We used gas chromatography/mass spectrometry to analyze baseline levels of testosterone in the prospective population-based MrOS (Osteoporotic Fractures in Men) Sweden study (2,416 men, age 69 to 81 years). SHBG was measured by immunoradiometric assay. CV clinical outcomes were obtained from central Swedish registers. Results: During a median 5-year follow-up, 485 CV events occurred. Both total testosterone and SHBG levels were inversely associated with the risk of CV events (trend over quartiles: p = 0.009 and p = 0.012, respectively). Men in the highest quartile of testosterone (

Original languageEnglish (US)
Pages (from-to)1674-1681
Number of pages8
JournalJournal of the American College of Cardiology
Volume58
Issue number16
DOIs
StatePublished - Oct 11 2011

Fingerprint

Osteoporotic Fractures
Sweden
Globulins
Testosterone
Serum
Independent Living
Immunoradiometric Assay
Metabolome
Adiposity
Gas Chromatography-Mass Spectrometry
Type 2 Diabetes Mellitus
Atherosclerosis
Prospective Studies
Population
Genes

Keywords

  • cardiovascular disease
  • men
  • testosterone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

High serum testosterone is associated with reduced risk of cardiovascular events in elderly men : The MrOS (osteoporotic fractures in men) study in Sweden. / Ohlsson, Claes; Barrett-Connor, Elizabeth; Bhasin, Shalender; Orwoll, Eric; Labrie, Fernand; Karlsson, Magnus K.; Ljunggren, Östen; Vandenput, Liesbeth; Mellström, Dan; Tivesten, Åsa.

In: Journal of the American College of Cardiology, Vol. 58, No. 16, 11.10.2011, p. 1674-1681.

Research output: Contribution to journalArticle

Ohlsson, C, Barrett-Connor, E, Bhasin, S, Orwoll, E, Labrie, F, Karlsson, MK, Ljunggren, Ö, Vandenput, L, Mellström, D & Tivesten, Å 2011, 'High serum testosterone is associated with reduced risk of cardiovascular events in elderly men: The MrOS (osteoporotic fractures in men) study in Sweden', Journal of the American College of Cardiology, vol. 58, no. 16, pp. 1674-1681. https://doi.org/10.1016/j.jacc.2011.07.019
Ohlsson, Claes ; Barrett-Connor, Elizabeth ; Bhasin, Shalender ; Orwoll, Eric ; Labrie, Fernand ; Karlsson, Magnus K. ; Ljunggren, Östen ; Vandenput, Liesbeth ; Mellström, Dan ; Tivesten, Åsa. / High serum testosterone is associated with reduced risk of cardiovascular events in elderly men : The MrOS (osteoporotic fractures in men) study in Sweden. In: Journal of the American College of Cardiology. 2011 ; Vol. 58, No. 16. pp. 1674-1681.
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