High prevalence of mumps in Lao People's Democratic Republic

J. M. Hübschen, K. Vilivong, C. Souvannaso, A. P. Black, N. Lütteke, B. Samountry, V. Phongsavath, B. Khamphaphongphane, Justin Denny, C. Sayyavong, G. K S Woo, K. Sengsaya, A. Sausy, P. Vongphrachanh, P. Jutavijittum, D. Phonekeo, C. P. Muller

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In the Lao People's Democratic Republic (PDR), mumps is not a notifiable disease and mumps vaccine is currently not included in the routine childhood immunization programme. In order to assess the burden of disease, we investigated the seroprevalence of mumps-specific IgG antibodies across four provinces. In addition, we genetically characterized mumps viruses from the past 3 years from several outbreaks and single cases. Blood and/or throat swabs from suspected cases were investigated for specific IgM antibodies or viral RNA. Mumps cases occurred between March and November in 2011-2013 and 5- to 15-year-olds were most affected. Four sequences from an outbreak in the north of Lao PDR in 2011 were identical and belonged to genotype G. Eight sequences from two outbreaks and two individual cases from 2012 and 2013 belonged to genotype J. In addition, sera collected from 2379 healthy infants and school pupils aged between 9 months and 19 years and from pregnant women aged between 16 and 46 years were investigated for mumps-specific IgG. Overall, 58.2% were positive, 39.5% were negative and the remaining 2.3% were equivocal. The seropositivity increased with age, with the lowest percentage found in

Original languageEnglish (US)
Pages (from-to)O664-O671
JournalClinical Microbiology and Infection
Volume20
Issue number10
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Fingerprint

Laos
Mumps
Disease Outbreaks
Mumps Vaccine
Immunoglobulin G
Genotype
Mumps virus
Immunization Programs
Antibodies
Seroepidemiologic Studies
Viral RNA
Pupil
Pharynx
Immunoglobulin M
Pregnant Women
Serum

Keywords

  • Genotype
  • Lao PDR
  • Mumps
  • Outbreak
  • Seroprevalence

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

Cite this

Hübschen, J. M., Vilivong, K., Souvannaso, C., Black, A. P., Lütteke, N., Samountry, B., ... Muller, C. P. (2014). High prevalence of mumps in Lao People's Democratic Republic. Clinical Microbiology and Infection, 20(10), O664-O671. https://doi.org/10.1111/1469-0691.12586

High prevalence of mumps in Lao People's Democratic Republic. / Hübschen, J. M.; Vilivong, K.; Souvannaso, C.; Black, A. P.; Lütteke, N.; Samountry, B.; Phongsavath, V.; Khamphaphongphane, B.; Denny, Justin; Sayyavong, C.; Woo, G. K S; Sengsaya, K.; Sausy, A.; Vongphrachanh, P.; Jutavijittum, P.; Phonekeo, D.; Muller, C. P.

In: Clinical Microbiology and Infection, Vol. 20, No. 10, 01.10.2014, p. O664-O671.

Research output: Contribution to journalArticle

Hübschen, JM, Vilivong, K, Souvannaso, C, Black, AP, Lütteke, N, Samountry, B, Phongsavath, V, Khamphaphongphane, B, Denny, J, Sayyavong, C, Woo, GKS, Sengsaya, K, Sausy, A, Vongphrachanh, P, Jutavijittum, P, Phonekeo, D & Muller, CP 2014, 'High prevalence of mumps in Lao People's Democratic Republic', Clinical Microbiology and Infection, vol. 20, no. 10, pp. O664-O671. https://doi.org/10.1111/1469-0691.12586
Hübschen JM, Vilivong K, Souvannaso C, Black AP, Lütteke N, Samountry B et al. High prevalence of mumps in Lao People's Democratic Republic. Clinical Microbiology and Infection. 2014 Oct 1;20(10):O664-O671. https://doi.org/10.1111/1469-0691.12586
Hübschen, J. M. ; Vilivong, K. ; Souvannaso, C. ; Black, A. P. ; Lütteke, N. ; Samountry, B. ; Phongsavath, V. ; Khamphaphongphane, B. ; Denny, Justin ; Sayyavong, C. ; Woo, G. K S ; Sengsaya, K. ; Sausy, A. ; Vongphrachanh, P. ; Jutavijittum, P. ; Phonekeo, D. ; Muller, C. P. / High prevalence of mumps in Lao People's Democratic Republic. In: Clinical Microbiology and Infection. 2014 ; Vol. 20, No. 10. pp. O664-O671.
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