High maternal HIV-1 viral load during pregnancy is associated with reduced placental transfer of measles IgG antibody

Carey Farquhar, Ruth Nduati, Nancy Haigwood, William Sutton, Dorothy Mbori-Ngacha, Barbra Richardson, Grace John-Stewart

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Background: Studies among HIV-1-infected women have demonstrated reduced placental transfer of IgG antibodies against measles and other pathogens. As a result, infants born to women with HIV-1 infection may not acquire adequate passive immunity in utero and this could contribute to high infant morbidity and mortality in this vulnerable population. Methods: To determine factors associated with decreased placental transfer of measles IgG, 55 HIV-1-infected pregnant women who were enrolled in a Nairobi perinatal HIV-1 transmission study were followed. Maternal CD4 count, HIV-1 viral load, and HIV-1-specific gp41 antibody concentrations were measured antenatally and at delivery. Measles IgG concentrations were assayed in maternal blood and infant cord blood obtained during delivery to calculate placental antibody transfer. Results: Among 40 women (73%) with positive measles titers, 30 (75%) were found to have abnormally low levels of maternofetal IgG transfer (

Original languageEnglish (US)
Pages (from-to)494-497
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume40
Issue number4
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

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Keywords

  • HIV-1-specific gp41 antibody
  • Maternal HIV-1 viral load
  • Measles IgG
  • Mother-to-child HIV-1 transmission
  • Placental antibody transfer

ASJC Scopus subject areas

  • Virology
  • Immunology

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