High-Frequency Monitoring for Early Detection of Cisplatin Ototoxicity

Stephen A. Fausti, James Henry, Heidi I. Schaffer, Deanna J. Olson, Richard H. Frey, Grover C. Bagby

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed. Serial conventional (0.25 to 8 kHz) and high-frequency (≥8 kHz) threshold monitoring was performed in patients receiving cisplatin, resulting in 84% of ears showing hearing loss, of which 71% were detected first in frequencies of 8 kHz or greater. By analysis according to an individualized, specific high-frequency range, early identification of hearing loss occurred in 94% of ears showing change. This five-frequency procedure is a sensitive detector of ototoxicity and is proposed as an alternative monitoring protocol for patients receiving cisplatin who cannot tolerate extended testing. (Arch Otolaryngol Head Neck Surg. 1993;119:661-666).

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume119
Issue number6
DOIs
StatePublished - 1993

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Cisplatin
Hearing Loss
Ear
Physiologic Monitoring
Hearing
Head

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

High-Frequency Monitoring for Early Detection of Cisplatin Ototoxicity. / Fausti, Stephen A.; Henry, James; Schaffer, Heidi I.; Olson, Deanna J.; Frey, Richard H.; Bagby, Grover C.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 119, No. 6, 1993, p. 661-666.

Research output: Contribution to journalArticle

Fausti, Stephen A. ; Henry, James ; Schaffer, Heidi I. ; Olson, Deanna J. ; Frey, Richard H. ; Bagby, Grover C. / High-Frequency Monitoring for Early Detection of Cisplatin Ototoxicity. In: Archives of Otolaryngology - Head and Neck Surgery. 1993 ; Vol. 119, No. 6. pp. 661-666.
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