Abstract
Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed. Serial conventional (0.25 to 8 kHz) and high-frequency (≥8 kHz) threshold monitoring was performed in patients receiving cisplatin, resulting in 84% of ears showing hearing loss, of which 71% were detected first in frequencies of 8 kHz or greater. By analysis according to an individualized, specific high-frequency range, early identification of hearing loss occurred in 94% of ears showing change. This five-frequency procedure is a sensitive detector of ototoxicity and is proposed as an alternative monitoring protocol for patients receiving cisplatin who cannot tolerate extended testing. (Arch Otolaryngol Head Neck Surg. 1993;119:661-666).
Original language | English (US) |
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Pages (from-to) | 661-666 |
Number of pages | 6 |
Journal | Archives of Otolaryngology--Head and Neck Surgery |
Volume | 119 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1993 |
ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology