High-frequency electromotile responses in the cochlea

Karl Grosh, Jiefu Zheng, Yuan Zou, Egbert De Boer, Alfred L. Nuttall

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Mammalian outer hair cells (OHCs) convert electrical energy into mechanical energy. The significance of this electromotility rests in the ability of the OHCs to modulate the vibrations of the cochlear partition in vivo. While high-frequency electromotility of isolated OHCs has been demonstrated at frequencies up to 100 kHz, a similar measure of the effect of OHC electromotility on motion of the sensory epithelium has not been made in vivo. In this study, in vivo electrical stimulation of the guinea pig cochlea is found to induce a mechanical response of the basilar membrane for frequencies to at least 100 kHz, nearly twice the upper limit of hearing for the guinea pig. The perfusion of salicylate in the cochlea reversibly reduces the electromotile response, indicating that an OHC-mediated process is the key contributor.

Original languageEnglish (US)
Pages (from-to)2178-2184
Number of pages7
JournalJournal of the Acoustical Society of America
Volume115
Issue number5 I
DOIs
StatePublished - May 2004

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Acoustics and Ultrasonics

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