High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate

Sarah M. Comstock, Lynley D. Pound, Jacalyn M. Bishop, Diana L. Takahashi, Ashley M. Kostrba, M. Susan Smith, Kevin L. Grove

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations

    Abstract

    We investigated the impact of poor maternal nutrition and metabolic health on the development of islets of the nonhuman primate (NHP). Interestingly, fetal offspring of high fat diet (HFD) fed animals had normal total islet and Β cell mass; however, there was a significant reduction in α cell mass, and decreased expression of transcription factors involved in α cell differentiation. In juvenile animals all offspring maintained on a HFD during the postweaning period demonstrated increases in total islet mass, however, the control offspring displaying increased islet number, and HFD offspring displayed increased islet size. Finally, while control offspring had increases in α and Β cells, the HFD offspring had increases only in Β cell number. These studies indicate that consumption of a HFD diet during pregnancy in the NHP, independent of maternal metabolic health, causes long-term abnormalities in α cell plasticity that may contribute to chronic disease susceptibility.

    Original languageEnglish (US)
    Pages (from-to)10-22
    Number of pages13
    JournalMolecular Metabolism
    Volume2
    Issue number1
    DOIs
    StatePublished - Feb 2013

    Keywords

    • CTR
    • Development
    • Diabetes
    • HFD
    • High fat diet
    • Obesity
    • Pancreas
    • Pregnancy

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

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