High dose rate radiation treatment of experimental intramuscular prostate carcinoma

Christina Skourou, P. Jack Hoopes, Summer L. Gibbs-Strauss, David J. Gladstone, Rendall Strawbridge, Keith D. Paulsen

Research output: Contribution to journalArticle

Abstract

Purpose: The Dunning R3327-MLL is a well established transplanted tumour line, and as such it makes a desirable model for evaluative studies of therapy. In the current study, the interstitial growth characteristics as well as the response of this tumour to a single fraction of high dose rate radiation is investigated. Materials and methods: The invitro response to radiation of the Dunning R3327-MLL was studied via a colony forming assay using a Cs-137 irradiator. In vitro radiosensitivity was determined on tumours implanted intramuscularly in the left gastrocnemius muscle of the rat and irradiated using an Ir-192 afterloader. Results: The results demonstrate a faster growth rate when compared to the reported subcutaneous growth rates. The Dunning R3327-MLL's radiosensitivity is comparable to that of late response tissues. The dose required to achieve a specific radiobiological response (the : ratio) of the invitro cell line is 2.4 Gy, whereas the ratio for the intramuscularly growing tumour was 0.99 Gy. Conclusions: These findings signify the intramuscularly implanted Dunning R3327-MLL tumour model as a desirable model for the study of single fraction high dose rate radiation treatments.

Original languageEnglish (US)
Pages (from-to)330-337
Number of pages8
JournalInternational Journal of Radiation Biology
Volume85
Issue number4
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

Keywords

  • Brachytherapy
  • Dunning R3327-MLL
  • Rat
  • Tumour radiosensitivity

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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