High dose calcitriol may reduce thrombosis in cancer patients

Tomasz M. Beer, Peter M. Venner, Christopher W. Ryan, Daniel P. Petrylak, Gurkamal Chatta, J. Dean Ruether, Kim N. Chi, John G. Curd, Thomas G. Deloughery

    Research output: Contribution to journalArticle

    57 Scopus citations

    Abstract

    The incidence of venous and arterial thrombosis in a placebo-controlled randomised trial of DN-101 (high dose calcitriol) with docetaxel versus docetaxel was compared. Of the 13 thrombotic events observed in the 250 patients enroled in this study, two occurred in DN-101 and 11 in placebo-treated patients (P = 0.01). This difference remained significant after adjustment for baseline history of thrombosis, atrial fibrillation and use of anti-thrombotic agents. In vitro and vitamin D receptor (VDR) knockout mouse studies predict that nanomolar concentrations of calcitriol may act as an antithrombotic agent. We report the first clinical observation that supports this hypothesis in humans.

    Original languageEnglish (US)
    Pages (from-to)392-394
    Number of pages3
    JournalBritish Journal of Haematology
    Volume135
    Issue number3
    DOIs
    StatePublished - Nov 1 2006

    Keywords

    • Calcitriol
    • Prostate cancer
    • Thromboembolism
    • Thrombosis
    • Vitamin D

    ASJC Scopus subject areas

    • Hematology

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