High dose calcitriol may reduce thrombosis in cancer patients

Tomasz (Tom) Beer, Peter M. Venner, Christopher Ryan, Daniel P. Petrylak, Gurkamal Chatta, J. Dean Ruether, Kim N. Chi, John G. Curd, Thomas Deloughery

    Research output: Contribution to journalArticle

    51 Citations (Scopus)

    Abstract

    The incidence of venous and arterial thrombosis in a placebo-controlled randomised trial of DN-101 (high dose calcitriol) with docetaxel versus docetaxel was compared. Of the 13 thrombotic events observed in the 250 patients enroled in this study, two occurred in DN-101 and 11 in placebo-treated patients (P = 0.01). This difference remained significant after adjustment for baseline history of thrombosis, atrial fibrillation and use of anti-thrombotic agents. In vitro and vitamin D receptor (VDR) knockout mouse studies predict that nanomolar concentrations of calcitriol may act as an antithrombotic agent. We report the first clinical observation that supports this hypothesis in humans.

    Original languageEnglish (US)
    Pages (from-to)392-394
    Number of pages3
    JournalBritish Journal of Haematology
    Volume135
    Issue number3
    DOIs
    StatePublished - Nov 2006

    Fingerprint

    docetaxel
    Calcitriol
    Thrombosis
    Placebos
    Calcitriol Receptors
    Fibrinolytic Agents
    Knockout Mice
    Venous Thrombosis
    Atrial Fibrillation
    Neoplasms
    Randomized Controlled Trials
    Observation
    Incidence

    Keywords

    • Calcitriol
    • Prostate cancer
    • Thromboembolism
    • Thrombosis
    • Vitamin D

    ASJC Scopus subject areas

    • Hematology

    Cite this

    High dose calcitriol may reduce thrombosis in cancer patients. / Beer, Tomasz (Tom); Venner, Peter M.; Ryan, Christopher; Petrylak, Daniel P.; Chatta, Gurkamal; Dean Ruether, J.; Chi, Kim N.; Curd, John G.; Deloughery, Thomas.

    In: British Journal of Haematology, Vol. 135, No. 3, 11.2006, p. 392-394.

    Research output: Contribution to journalArticle

    Beer, TT, Venner, PM, Ryan, C, Petrylak, DP, Chatta, G, Dean Ruether, J, Chi, KN, Curd, JG & Deloughery, T 2006, 'High dose calcitriol may reduce thrombosis in cancer patients', British Journal of Haematology, vol. 135, no. 3, pp. 392-394. https://doi.org/10.1111/j.1365-2141.2006.06322.x
    Beer, Tomasz (Tom) ; Venner, Peter M. ; Ryan, Christopher ; Petrylak, Daniel P. ; Chatta, Gurkamal ; Dean Ruether, J. ; Chi, Kim N. ; Curd, John G. ; Deloughery, Thomas. / High dose calcitriol may reduce thrombosis in cancer patients. In: British Journal of Haematology. 2006 ; Vol. 135, No. 3. pp. 392-394.
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    AU - Venner, Peter M.

    AU - Ryan, Christopher

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    AU - Chatta, Gurkamal

    AU - Dean Ruether, J.

    AU - Chi, Kim N.

    AU - Curd, John G.

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