High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease

Vidya M.Raj Krishnamurthy, Guo Wei, Bradley C. Baird, Maureen Murtaugh, Michel B. Chonchol, Kalani L. Raphael, Tom Greene, Srinivasan Beddhu

Research output: Contribution to journalArticlepeer-review

190 Scopus citations

Abstract

Chronic kidney disease is considered an inflammatory state and a high fiber intake is associated with decreased inflammation in the general population. Here, we determined whether fiber intake is associated with decreased inflammation and mortality in chronic kidney disease, and whether kidney disease modifies the associations of fiber intake with inflammation and mortality. To do this, we analyzed data from 14,543 participants in the National Health and Nutrition Examination Survey III. The prevalence of chronic kidney disease (estimated glomerular filtration rate less than 60 ml/min per 1.73 m 2) was 5.8%. For each 10-g/day increase in total fiber intake, the odds of elevated serum C-reactive protein levels were decreased by 11% and 38% in those without and with kidney disease, respectively. Dietary total fiber intake was not significantly associated with mortality in those without but was inversely related to mortality in those with kidney disease. The relationship of total fiber with inflammation and mortality differed significantly in those with and without kidney disease. Thus, high dietary total fiber intake is associated with lower risk of inflammation and mortality in kidney disease and these associations are stronger in magnitude in those with kidney disease. Interventional trials are needed to establish the effects of fiber intake on inflammation and mortality in kidney disease.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalKidney International
Volume81
Issue number3
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

Keywords

  • all-cause mortality
  • chronic kidney disease
  • inflammation

ASJC Scopus subject areas

  • Nephrology

Fingerprint

Dive into the research topics of 'High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease'. Together they form a unique fingerprint.

Cite this