HIF Gene Expression in Cancer Therapy

Denise A. Chan, Adam J. Krieg, Sandra Turcotte, Amato J. Giaccia

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations

Abstract

Tumor hypoxia is a feature common to almost all solid tumors due to malformed vasculature and inadequate perfusion. Tumor cells have evolved mechanisms that allow them to respond and adapt to a hypoxic microenvironment. The hypoxia-inducible transcription factor (HIF) family is comprised of oxygen-sensitive alpha (α) subunits that respond rapidly to decreased oxygen levels and oxygen-insensitive beta (β) subunits. HIF binds to specific recognition sequences in the genome and increases the transcription of genes involved in a variety of metabolic and enzymatic pathways that are necessary for cells to respond to an oxygen-poor environment. The critical role of this family of transcriptional regulators in maintaining oxygen homeostasis is supported by multiple regulatory mechanisms that allow the cell to control the levels of HIF as well as its transcriptional activity. This review will focus on how the transcriptional activity of HIF is studied and how it can be exploited for cancer therapy.

Original languageEnglish (US)
Title of host publicationOxygen Biology and Hypoxia
EditorsHelmut Sies, Bernhard Brune
Pages323-345
Number of pages23
DOIs
StatePublished - Dec 1 2007

Publication series

NameMethods in Enzymology
Volume435
ISSN (Print)0076-6879

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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    Chan, D. A., Krieg, A. J., Turcotte, S., & Giaccia, A. J. (2007). HIF Gene Expression in Cancer Therapy. In H. Sies, & B. Brune (Eds.), Oxygen Biology and Hypoxia (pp. 323-345). (Methods in Enzymology; Vol. 435). https://doi.org/10.1016/S0076-6879(07)35016-7