Hibernation, hypothermia and a possible therapeutic "shifted homeostasis" induced by central activation of a1 adenosine receptor (A1AR)

Domenico Tupone, Justin S. Cetas, Shaun F. Morrison

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Pharmacological manipulation of central autonomic thermoregulatory circuits could represent a potential target for the induction of a hypothermic state. Here we present a brief description of the CNS thermoregulatory centers and how the manipulation of these circuits can be useful in the treatment of pathological conditions such as stroke or brain hemorrhage.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalJapanese Journal of Neuropsychopharmacology
Volume36
Issue number2
StatePublished - Apr 2016

Keywords

  • Brain hemorrhage
  • Brown adipose tissue
  • Hypothermia
  • Stroke
  • Thermoregulation

ASJC Scopus subject areas

  • Clinical Psychology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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