Hibernation, hypothermia and a possible therapeutic "shifted homeostasis" induced by central activation of a1 adenosine receptor (A1AR)

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Pharmacological manipulation of central autonomic thermoregulatory circuits could represent a potential target for the induction of a hypothermic state. Here we present a brief description of the CNS thermoregulatory centers and how the manipulation of these circuits can be useful in the treatment of pathological conditions such as stroke or brain hemorrhage.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalJapanese Journal of Neuropsychopharmacology
Volume36
Issue number2
StatePublished - Apr 1 2016

Fingerprint

Adenosine A1 Receptors
Hibernation
Hypothermia
Homeostasis
Pharmacology
Intracranial Hemorrhages
Ischemia
Stroke
Brain
Therapeutics
Research

Keywords

  • Brain hemorrhage
  • Brown adipose tissue
  • Hypothermia
  • Stroke
  • Thermoregulation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Pharmacology (medical)
  • Pharmacology

Cite this

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AU - Tupone, Domenico

AU - Cetas, Justin

AU - Morrison, Shaun

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N2 - The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Pharmacological manipulation of central autonomic thermoregulatory circuits could represent a potential target for the induction of a hypothermic state. Here we present a brief description of the CNS thermoregulatory centers and how the manipulation of these circuits can be useful in the treatment of pathological conditions such as stroke or brain hemorrhage.

AB - The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Pharmacological manipulation of central autonomic thermoregulatory circuits could represent a potential target for the induction of a hypothermic state. Here we present a brief description of the CNS thermoregulatory centers and how the manipulation of these circuits can be useful in the treatment of pathological conditions such as stroke or brain hemorrhage.

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KW - Thermoregulation

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JF - Japanese Journal of Psychopharmacology

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