Hibernating myocardium: a hypometabolic state for energy conservation

G. A. Pantely, J. D. Bristow

    Research output: Contribution to journalArticle

    6 Scopus citations

    Abstract

    Moderately hypoperfused myocardium in animals initiates an active process that transiently reduces regional energy consumption below that required by the reduced flow. This eliminates most metabolic abnormalities of ischemia despite ongoing hypoperfusion. These interesting early metabolic adaptations help to confirm the concept of hibernating myocardium, a hypometabolic state for energy conservation. A similar metabolic response probably can occur in human myocardium. However, the complexities of coronary disease may make it difficult to demonstrate these metabolic adaptations in chronically hypofunctioning myocardium in humans.

    Original languageEnglish (US)
    Pages (from-to)23-25
    Number of pages3
    JournalBasic Research in Cardiology
    Volume90
    Issue number1
    DOIs
    StatePublished - Jan 1 1995

    Keywords

    • Myocardial ischemia
    • myocardial metabolism

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

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