Heterotransplantation of human choroidal melanoma into the athymic 'nude' mouse

D. M. Albert, M. D. Wagoner, K. Moazed, G. P. Kimball, J. R. Gonder

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The investigation of the structure and behavior of malignant melanoma of the uveal tract in man has been limited by the lack of a ready source of human tumor and an animal model in which the tumor resembles that in the human choroid. The authors now report the observation that fresh surgical specimens of human choroidal melanoma can be successfully transplanted into the posterior segment of the 'nude' mouse (a homozygous mutant, nu/nu, with a defect in cellular immunity) and can be serially transplanted. This model utilizing human melanoma should be useful for the study of the natural history of this disease, as well as the response to various chemotherapeutic agents.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume19
Issue number5
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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