Heterogeneity of acute “undifferentiated” leukemia of childhood: Ultrastructural, immunophenotypic, and karyotypic analyses

Linda Stork, Harry Wilson, Gary Mierau, Taru Hays, Helvise Morse, Bette Jamieson, Lynn Barczuk, Rebecca Berry, Lorrie Odom

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The present study was undertaken in an attempt to reclassify the 19 cases of childhood acute undifferentiated leukemia (AUL) diagnosed at our institution during the past 12 years. Based on ultrastructural and immunophenotypic data, seven of the cases were reclassified as lymphoid, nine as myeloid, and three remain unclassifiable. Clinical features, clonal karyotypes, and responses to treatment were also examined. Abnormal clonal karyotypes were found in 16 of 17 cases, including eight cases with translocations, three with monosomy 7 or 7q, and one with numerous complex structural rearrangements. Fourteen patients had > 10% French-American-British L2 blasts in bone marrow. Although nine of 15 patients who initially received induction therapy for acute lymphoblastic leukemia (ALL) achieved remission, only one patient is a long-term survivor. Only one of 10 patients who received therapy for acute nonlymphoblastic leukemia during the course of their disease remains a long-term survivor. These data suggest that the majority of cases of AUL can be reclassified as either myeloid or lymphoid leuke-mias, that AUL is associated with a high frequency of chromosomal abnormalities, and that AUL carries a very poor prognosis.

Original languageEnglish (US)
Pages (from-to)34-44
Number of pages11
JournalJournal of Pediatric Hematology/Oncology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 1990

Keywords

  • Acute undifferentiated leukemia
  • Childhood
  • French-American-British (FAB) L/L
  • Immunophenotype
  • Megakaryocytic leukemia
  • Monosomy 7/7q
  • Poor prognosis
  • Translocations
  • Ultrastructure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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