Herpesviruses remodel host membranes for virus egress

David C. Johnson; Joel D. Baines

doi:10.1038/nrmicro2559

Herpesviruses remodel host membranes for virus egress

David C. Johnson, Joel D. Baines

Molecular Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

368 Scopus citations

Abstract

Herpesviruses replicate their DNA and package this DNA into capsids in the nucleus. These capsids then face substantial obstacles to their release from cells. Unlike other DNA viruses, herpesviruses do not depend on disruption of nuclear and cytoplasmic membranes for their release. Enveloped particles are formed by budding through inner nuclear membranes, and then these perinuclear enveloped particles fuse with outer nuclear membranes. Unenveloped capsids in the cytoplasm are decorated with tegument proteins and then undergo secondary envelopment by budding into trans-Golgi network membranes, producing infectious particles that are released. In this Review, we describe the remodelling of host membranes that facilitates herpesvirus egress.

Original language	English (US)
Pages (from-to)	382-394
Number of pages	13
Journal	Nature Reviews Microbiology
Volume	9
Issue number	5
DOIs	https://doi.org/10.1038/nrmicro2559
State	Published - May 2011

ASJC Scopus subject areas

Microbiology
General Immunology and Microbiology
Infectious Diseases

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10.1038/nrmicro2559

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title = "Herpesviruses remodel host membranes for virus egress",

abstract = "Herpesviruses replicate their DNA and package this DNA into capsids in the nucleus. These capsids then face substantial obstacles to their release from cells. Unlike other DNA viruses, herpesviruses do not depend on disruption of nuclear and cytoplasmic membranes for their release. Enveloped particles are formed by budding through inner nuclear membranes, and then these perinuclear enveloped particles fuse with outer nuclear membranes. Unenveloped capsids in the cytoplasm are decorated with tegument proteins and then undergo secondary envelopment by budding into trans-Golgi network membranes, producing infectious particles that are released. In this Review, we describe the remodelling of host membranes that facilitates herpesvirus egress.",

author = "Johnson, {David C.} and Baines, {Joel D.}",

note = "Funding Information: Studies in the Baines laboratory were supported by US National Institutes of Health (NIH) grants R01 AI52341 and R01 GM50740. The work in the Johnson laboratory was supported by NIH grants R01 EY018755 and R01 AI081517. We thank T. Howard for helping to create the figures, and M. Webb for the electron microscopy images in figure 2.",

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AB - Herpesviruses replicate their DNA and package this DNA into capsids in the nucleus. These capsids then face substantial obstacles to their release from cells. Unlike other DNA viruses, herpesviruses do not depend on disruption of nuclear and cytoplasmic membranes for their release. Enveloped particles are formed by budding through inner nuclear membranes, and then these perinuclear enveloped particles fuse with outer nuclear membranes. Unenveloped capsids in the cytoplasm are decorated with tegument proteins and then undergo secondary envelopment by budding into trans-Golgi network membranes, producing infectious particles that are released. In this Review, we describe the remodelling of host membranes that facilitates herpesvirus egress.

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Herpesviruses remodel host membranes for virus egress

Abstract

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